三阴性乳腺癌与非三阴性乳腺癌临床病理特征比较及预后因素分析

Clinicopathological Features and Prognostic fFacotors of Triple Negative Breast Cancer and Non-triple Negative Breast Cancer

目的探讨三阴性乳腺癌与非三阴性乳腺癌相关的临床病理特征和预后影响因素。方法收集184例乳腺癌患者的临床资料和病理资料。将患者随机分为2组,A组(三阴性乳腺癌)60例与B组(非三阴性乳腺癌)124例。对2组患者地体质特征和肿瘤特征进行比较,并对184例患者的预后结果进行分析。结果 A组和B组患者在发病年龄,乳腺癌家族史,肿瘤大小,肿瘤组织学分级,淋巴结阳性和转移状态方面存在显著差异。同时,2组在5年,7年和9年无病生存率及7年,9年总生存率方面,差异有统计学意义。结论三阴乳腺癌与发病年龄、家族遗传史、肿瘤大小、腋窝淋巴结阳性率、肿瘤组织学分级有关,癌症转移风险高,预后差。

Objective To determine the clinicopathological features and prognostic factors between triple-negative breast cancer(TNBC) and non-triple negative breast cancer (non-TNBC).Methods Clinicopathological data of 184 breast cancer pa-tients were collected .Patients were divided into 2 groups:group A were 60 cases of TNBC patients and group B were 124 cases of non-TNBC patients.Physical quality of patients and tumor characteristics were compared between the 2 groups.The prognostic re-sults of 184 patients were analyzed .Results There had significant differences in disease onset age ,family history of breast canc-er,tumor size,tumor histologic grade,lymph note positivity and metastatic status between TNBC and non-TNBC patients.There were significant differences in 5-,7-and 9-year disease-free survival rates and 7-and 9-year overall survival rates between the 2 groups.Conclusion TNBC is related with age ,family history of breast cancer ,tumor size,axillary lymph node positive rate and tumor histological grade .It has high risk of metastasis and poor prognosis .