喉癌患者血清、唾液及组织中VEGF及MMP的表达及其临床意义

Expression of VEGF and MMP in Serum,Ptysma and Tissues of Laryngocarcinoma Patients and Their Clinical Significance

目的探讨喉癌患者血清、唾液及组织中VEGF及MMP的表达情况。方法选取65例喉癌患者为观察组,并以同期的65例声带息肉患者为对照组,然后将2组患者的血清、唾液及组织中VEGF-C、VEGF-D及MMP-2、MMP-9、MMP-13表达情况进行检测及比较,同时比较观察组中不同分期喉癌患者的血清、唾液及组织检测结果。结果观察组的血清及组织中VEGF-C、VEGF-D及MMP-2、MMP-9、MMP-13表达均高于对照组,且观察组中分期较高者的表达均高于分期较低者(P均<0.05),而2组患者及观察组中不同分期者的唾液检测结果则无明显差异(P均>0.05)。结论喉癌患者血清及组织中VEGF及MMP表达变化较大,但唾液检测结果则差异不明显,因此认为对喉癌患者进行血清及组织上述指标的检测价值较高。

Objective To observe and investigate the expression of VEGF and MMP in serum ,ptysma and tissues of la-ryngocarcinoma patients .Methods 65 patients with laryngocarcinoma were selected as the observation group ,65 patients with polyp of cord were selected as the control group ,the expression of VEGF-C,VEGF-D and MMP-2,MMP-9,MMP-13 in serum, ptysma and tissues of the 2 groups were detected and compared ,and serum,ptysma and tissues in different stages of laryngocarci-noma in the observation group were compared .Results The serum and tissues expression of VEGF-C,VEGF-D and MMP-2, MMP-9,MMP-13 in the observation group were all higher than those of the control group ,and the expression of higher stages were all higher than those of the lower stages in the observation group ,all P<0.05,there were significant differences .Ptysma detection results of the 2 groups and in different stages had no obvious differences ,all P>0.05.Conclusion The changes of serum and tissue expression of VEGF and MMP of patients with laryngocarcinoma are great ,while the ptysma detection results have no obvi-ous differences ,the serum and tissues detection value is relatively higher .