嗜酸性粒细胞及营养状况与肺癌患者预后的关系

The Relationship of Eosinophile Granulocyte and Nutritional Status with the Prognosis of Lung Cancer

目的探讨嗜酸性粒细胞及营养状况与肺癌患者预后之间的关系。方法选择60例肺癌患者为研究对象,检测患者嗜酸性粒细胞、血红蛋白、血脂、白蛋白等指标,并分析其与患者生存期的关系。结果 60例患者均得到随访,随访时间为2~30个月,中位随访时间22.8个月。60例患者1年、2年生存率分别为58.3%和48.3%;嗜酸性粒细胞增高者与正常者2年生存率分别为20.0%和54.0%(P<0.05);贫血与非贫血患者2年生存率分别为30.8%和61.8%(P<0.05);营养不良者与未发生营养不良者2年生存率分别为21.4%和56.5%(P<0.05)。单因素分析结果显示:嗜酸性粒细胞、血红蛋白、BMI、白蛋白与患者生存期相关(P<0.05);多因素分析结果显示:嗜酸性粒细胞及白蛋白是影响患者2年生存期的独立因素。结论嗜酸性粒细胞及白蛋白是影响患者预后的独立因素,改善患者营养状况有益于改善预后。

Objective To explore the relationship of eosinophile granulocyte and nutritional status with the prognosis of lung cancer.Methods 60 cases with lung cancer were selected as research subjects .Eosinophile granulocyte ,hemoglobin,blood lipid and albumin were detected and their relationship with survival time were studied .Results 60 patients received follow up . The follow-up time was 2 ~30 months,and the median follow-up time was 22.8 months.The 1-and 2-year survival rates were 58.3%and 48.3%.2-year survival rates of patients with increased eosinophile granulocyte and normal eosinophile granulocyte were 20.0%and 54.0%(P<0.05),2-year survival rates of patients with and without anemia were 30.8% and 61.8%(P<0.05),2-year survival rates of patients with and without malnutrition were 21.4%and 56.5%(P<0.05).Single factor analysis showed that eosinophile granulocyte ,hemoglobin,BMI and albumin were related with survival time;Multivariate analysis showed that eosinophile granulocyte and albumin were independence factors influencing 2-year survival rates .Conclusion Eosinophile granulocyte and albumin are independence influencing factors of prognosis .Improvement of nutritional status are benefitial to prog-nosis.