摘要
目的探讨精子蛋白32前体对脑胶质瘤预后的影响。方法运用免疫组织化学法以及聚合酶链反应即PCR检测54例脑胶质瘤患者精子蛋白32前体(OY.TES-1)mRNA和其表达的蛋白。常规治疗后对患者生存率与复发情况进行随访观察。并运用统计学原理分析精子蛋白32前体与脑胶质瘤复发的关系。结果肿瘤精子蛋白32前体mRNA阳性患者复发率为93.55%,其表达蛋白阳性复发率为94.44%。肿瘤精子蛋白32前体mRNA与其表达蛋白复发率为78.26%。结论诊断脑胶质瘤时,检测精子蛋白32前体(OY.TES-1)mRNA有助于判断脑胶质瘤复发的情况。
Objective To analysis the effect of sperm protein 32 precursor on prognosis of glioma. Methods The expression of sperm protein 32 precursor mRNA and protein in 54 patients with glioma were detected by PCR and immunohistochemistry. Survival and recurrence were observed during follow-up. Use statistics to analyze the relationship between sperm protein 32 precursor and recurrence of glioma. Results Recurrence rates of patients with positive sperm protein 32 precursor mRNA were93. 55%,positive recurrence rate of protein expression was 94. 44%. Recurrence rate of sperm protein 32 precursor mRNA and protein expression was 78. 26%. Conclusion In the diagnosis of glioma,the detection of sperm protein 32 precursor( OY. TES-1) mRNA help to determine recurrence of glioma.
出处
《实用癌症杂志》
2015年第1期51-53,共3页
The Practical Journal of Cancer
