香菇多糖注射液联合FOLFOX方案治疗晚期结肠癌的效果观察

Effect of Lentinan Injection Combined FOLFOX for Advanced Colon Cancer

目的探讨香菇多糖注射液联合FOLFOX方案治疗晚期结肠癌的临床疗效。方法将90例晚期结肠癌患者按照住院时间先后顺序分组为对照组和治疗组。对照组:采用亚叶酸钙,200 mg/m2,静脉滴入,1次/天;奥沙利铂,100 mg/m2,静脉滴入,1次/天;5-氟尿嘧啶,400 mg/m2,静脉滴注,1次/天;5-氟尿嘧啶,600 mg/m2,持续静脉泵入22 h,d1-2。治疗组:在对照组治疗基础上,同时给患者采用香菇多糖注射液1 mg,2次/周,静脉滴注。观察2组患者的近、远期疗效和不良反应及对细胞因子的影响。结果治疗后,治疗组1、2、3年生存率分别为75.56%(34/45)、55.56%(25/45)、37.78%(17/45),与对照组71.11%(32/45)、35.56%(16/45)、24.44%(11/45)比较,1年生存率差异无统计学意义(P>0.05),2、3年生存率差异有统计学意义(P<0.05)。此外,2组患者近期临床疗效和不良反应比较,P均<0.05。2组患者治疗后血清IL-2和TNF-α及IFN-γ水平与治疗前比较,均出现明显上升,但治疗组升高较为显著(P<0.05)。结论相比FOLFOX方案化疗来说,采用香菇多糖注射液联合FOLFOX方案治疗晚期结肠癌,能提高患者近、远期疗效,且不良反应少,同时还能有效改善患者免疫功能,提高患者抵抗力。

Objective To explore the clinical curative effect of lentinan injection combined FOLFOX for advanced colorectal cancer. Methods 90 cases of patients with advanced colon cancer were divided into the control group and the treatment group. Control group received calcium leucovorin,200 mg / m2,intravenous drip,once/d; Oxaliplatin,100 mg/m2,intravenous drip,once / d; 5-fluorouracil,400 mg / m2,the intravenous drip,once/d; 5-fluorouracil,600 mg/m2,continuous intravenous pumping22 h and d1-2. Treatment group received additional lentinan injection 1 mg,twice / week,intravenous drip on the basis of the control treatment. The short-term and long-term curative effects,adverse reaction and the influence of cytokines of the 2 groups were observed. Results After treatment,1-,2-,3-year survival rates of the treatment group were 75. 56%( 34 /45),55. 56%( 25 /45),37. 78%( 17 /45),and those of the control group were 71. 11%( 32 /45),35. 56%( 16 /45),24. 44%( 11 /45),there was no statistically significant difference in 1-year survival rate( P > 0. 05),2-,3-year survival rate had statistically significant difference( P < 0. 05). In addition,recent clinical curative effect and adverse reactions of the 2 groups had statistically significant difference,P < 0. 05. Serum IL-2,TNF alpha and IFN-gamma levels of the 2 groups after treatment had statistically significant difference,and treatment group had higher increase( P < 0. 05). Conclusion Compared with FOLFOX schemes,lentinan injection combined with FOLFOX regimen for advanced colon cancer can improve short-term and long-term curative effects,with less adverse reactions,and it can effectively improve the patients’ immune function and resistance.