膀胱癌患者尿液中BLCA-4表达的临床意义

Clinical Significance of Expression of BLCA-4 in Urine of Bladder Cancer Patients

目的探讨膀胱癌患者尿液特异性核基质蛋白-4(BLCA-4)的表达及临床意义。方法以80例初诊膀胱癌患者为研究对象,选择50例膀胱炎患者及50例健康体检者为对照。比较三组患者尿液中BLCA-4表达的差异及其与膀胱癌患者临床病理指标的关系。结果膀胱癌患者尿液中BLCA-4水平显著高于膀胱炎患者及健康体检者,差异具有统计学意义(P<0.05),膀胱炎及健康体检者之间未见统计学差异(P>0.05);BLCA-4对膀胱癌的诊断灵敏度为93.8%,特异度为100.0%;BLCA-4与膀胱癌患者年龄、性别、病理分级、肿瘤大小及临床分期等因素均无相关性(P>0.05);复发患者与未复发患者术前及术后6个月尿液中BLCA-4水平比较均无显著差别(P>0.05),两组患者术后6个月BLCA-4水平均显著下降(P<0.05),但术后1年6例复发患者尿液BLCA-4水平均显著高于术后6个月水平(P<0.05),且与未复发患者相比差异具有统计学意义(P<0.05)。结论 BLCA-4对膀胱癌诊断敏感度高,加强对膀胱癌患者术后BLCA-4水平的监测有助于预测复发情况。

Objective To explore the expression of bladder cancer specific nuclear matrix protein 4( BLCA-4) in urine of bladder cancer patients and its clinical significance. Methods 80 cases of newly diagnosed bladder cancer patients were selected as research subjects,and 50 cystitis cases and 50 healthy patients as control subjects. The urine levels of BLCA-4 among the 3 groups were compared and the relationship with clinicopathological indicators were explored. Results The urine level of BLCA-4 in bladder cancer patients was significantly higher than that of cystitis patients and healthy patients( P < 0. 05); There were no significant difference in BLCA-4 between cystitis patients and healthy patients( P > 0. 05); The sensitivity of BLCA-4 for bladder cancer was 93. 8% and specificity was 100. 0%; BLCA-4 had no relationship with age,sex,pathological grading,tumor size and clinical stage( P > 0. 05); There were no significant difference in BLCA-4 before operation and 6 months after operation between the patients with and without recurrence( P > 0. 05); The BLCA-4 level greatly decreased 6 months after operation in patients with and without recurrence( P < 0. 05); 1 year after operation,the BLCA-4 level in 6 patients with recurrence was significantly higher than 6 months after operation,There were significant difference compared with patients without recurrence( P <0. 05). Conclusion BLCA-4 has high sensitivity for bladder cancer. Enhancing monitoring of BLCA-4 is benefical for evaluating recurrence.