干扰素-α在治疗慢性粒细胞白血病患者中的综合应用价值

Research about the Integrated Value of Interferon-α for Patients with Chronic Myelocytic Leukemia

目的分析干扰素-α对慢性粒细胞白血病(CML)血清疾病相关细胞因子水平的影响,探讨其综合应用价值。方法 60例CML患者作为观察组及30例正常健康人群作为正常对照组,60例CML患者又随机分为2组,对照组和干扰素治疗组各30例。比较不同人群间血清PGE-2、MMP-2、b FGF、ALP及IL-6等细胞因子水平差异。比较对照组和干扰素治疗组患者采用干扰素-α治疗前后血清上述细胞因子水平以及疗效差异。结果 CML血清PGE-2、MMP-2、b FGF、ALP及IL-6水平显著高于正常对照组,P<0.05。干扰素治疗组治疗6周后血清PGE-2、MMP-2、b FGF、ALP及IL-6水平显著低于对照组,疗效指标CHR、CCyR、CMR则显著优于对照组,P<0.05。结论干扰素-α对肿瘤生长相关的细胞因子具有调节作用,能有效缓解CML患者临床症状,在CML治疗中具有积极的意义。

Objective To study the integrated value of interferon-α for patients with chronic myelocytic leukemia( CML). Methods 60 cases of CML were selected as the observation group,30 cases of normal healthy people were selected as the normal control group,60 cases of CML were randomly divided into the control group and interferon treatment group. Then the indexes of PGE-2,MMP-2,b FGF,ALP and IL-6 among different populations were compared. And these indicators and efficacy between the control group and interferon treatment group before and after treatment were also compared. Results The serum levels of PGE-2,MMP-2,b FGF,ALP and IL-6 of patients with CML were all higher than those of the normal control group,P < 0. 05. After 6 weeks of treatment,the serum levels of PGE-2,MMP-2,b FGF,ALP and IL-6 of interferon treatment group were all lower than those of the control group,while the indicators of efficacy such as CHR,CCyR,CMR were all better than those of the control group,all P < 0. 05。Conclusion Interferon-α can effectively regulate the growth related cytokines tumor,and relieve clinical symptoms of patients with CML,it has positive implications in the treatment of CML.