新辅助化疗对进展期食管癌患者生存状况的影响

Effect of Neoadjuvant Chemotherapy on the Living Conditions of Patients with Advanced Esophageal Carcinoma

目的探讨新辅助化疗对进展期食管癌患者生存状况的影响。方法对51例进展期食管癌患者的病案资料进行回顾性分析,其中,单纯行手术治疗31例(对照组),新辅助化疗+手术治疗20例(观察组),对比2组患者的预后状况。结果观察组患者的5年生存率显著高于对照组患者,差异有统计学意义(P<0.05);2组患者术后观察组局部复发率、远处转移率、并发症发生率对比,差异不具有统计学意义(P均>0.05)。结论新辅助化疗可显著提高进展期食管癌患者的生存率,且未增加术后局部复发、远处转移及并发症发生的风险,是安全可行的治疗方案。

Objective To investigate the influence of neoadjuvant chemotherapy on the living conditions of patients with advanced esophageal carcinoma. Methods The clinical data of 51 cases of patients with advanced esophageal carcinoma were retrospectively analyzed. 31 cases were treated only by surgical treatment( control group),20 cases were treated with neoadjuvant chemotherapy followed by surgery( observation group),and the prognosis of the 2 groups were compared. Results The 5-year survival rate of the observation group were significantly higher than that of the control group,the differences were statistically significant( all P < 0. 05). The differences of the 2 groups in the local recurrence rates,distant metastasis rates,the rates of complications after operation were no significant( all P > 0. 05). Conclusion Neoadjuvant chemotherapy can significantly improve the survival rate of patients with advanced esophageal carcinoma,without increasing the rate of local recurrence,distant metastasis,and postoperative complications,it is a safe and feasible treatment.