初治鼻咽癌单纯常规外照射放疗的临床效果及其影响因素分析

Analysis of Clinical Efficacy and Influencing Factors of Conventional External Beam Radiotherapy Alone for Primary Nasopharyngeal Carcinoma(PNC)

目的探讨单纯常规外照射放疗对初治鼻咽癌的临床效果及其影响因素分析。方法对110例行常规放疗的原发鼻咽癌患者进行单纯常规外照射放疗,评价临床效果,并随访病例。运用Cox回归模型分析5年存活率的相关影响因素。结果 110例鼻咽癌患者经照射放疗后,显效75例,有效27例,无效8例,治疗有效率为92.7%。5年内死亡47例,存活63例,5年总生存率为57.3%。对疗效影响因素进行单因素分析,结果显示患者年龄、临床分期、T分期、N分期、颅神经受侵、颅底受侵、放疗剂量及PS评分与鼻咽癌的放疗预后呈显著相关(P<0.05);Cox回归分析结果显示,患者年龄、T分期、N分期与是否出现颅底受侵可作为鼻咽癌放疗的独立预后因素(P<0.05)。结论采用单纯常规外照射放疗治疗鼻咽癌效果显著,安全性高;年龄、T、N分期以及是否出现颅底受侵为鼻咽癌放射治疗的独立预后因素。

Objective To discuss the clinical effects and influencing factors of conventional external beam radiotherapy alone for primary nasopharyngeal carcinoma(PNC).Methods 110 cases of PNC received conventional radiotherapy were chosen as research objects,and were given conventional external beam radiotherapy alone.Clinical effect was evaluated and patients were given follow-up visits.Relevant influencing factors of 5-year survival rate were analyzed by Cox regression model.Results After radiotherapy,among 110 patients,there were 75 cases with excellent clinical effects,27 with good clinical effects and 8 with no clinical effects,and total effective rate was 92.7%; within 5 years,47 patients died and 63 survived,and 5-year survival rate was 57.3%; single factor analysis showed that,age,clinical stage,T stage,N stage,cranial nerve erosion,skull base erosion,radiotherapy dose and PS score were closely related to prognosis of PNC after radiotherapy(P < 0.05).Cox regression analysis showed that age,T stage,N stage,whether there was skull base erosion,were independent prognosis factors of PNC after radiotherapy(P< 0.05).Conclusion Conventional external beam radiotherapy alone for PNC has obvious clinical effects and high safety; age,T stage,N stage,whether there is skull base erosion,are independent prognosis factors of PNC after radiotherapy.