不同微创介入方案对肝癌患者的疗效对比

Comparison of Efficacy of Different Minimally Invasive Solutions for Hepatocellular Carcinoma

目的比较不同微创介入方案(肝动脉栓塞化疗TACE,射频消融RFA)对肝癌患者的疗效。方法 46例肝癌患者(Child-Pugh分级A级或B组):20例行TACE治疗(TACE组),26例行RFA(RFA组)治疗。结果随访时间1~51个月,平均15个月。首次CT检查发现RFA组17例(66.7%)肿瘤血管完全断流,TACE组11例(56.9%)肿瘤血管完全断流(P=0.0065)。肝功能损害为最主要的并发症,两组并发症发生率比较差异具有统计学意义(P=0.004)。中位生存率RFA组为70.4%,TACE组为41.7%,P=0.051,差异具有统计学意义。Kaplan-Meier法分析显示,RFA组1、3、5年生存率分别为89.7%、67.1%和30.5%.;TACE组1、3、5年生存率分别为68.9%、46.2%和16.4%。结论射频消融治疗肝癌具有较高的局部缓解作用,效果优于肝动脉栓塞化疗方案。

Objective To compare the efficacy of different minimally invasive solutions(TACE,RFA) for liver cancer.Methods 46 cases of liver cancer patients were divided into 2 groups.20 patients received TACE(TACE group),26 cases received RFA(RFA group).Results Follow up was 1 ~ 51 months,mean time was 15 months.The first CT examination revealed that in RFA group 17(66.7%) cases had tumor blood vessels completely dried up,in TACE group 11(56.9%) cases had tumor blood vessels completely dried up(P = 0.0065).Liver damage was the main complications,there had significant difference in complications between the 2 groups(P = 0.004).The median survival rate of RFA group and TACE group were 70.4% and41.7%(P = 0.051),the difference was statistically significant.Kaplan-Meier analysis showed that 1,3,5-year survival rates of RFA group were 89.7%,67.1% and 30.5%,and those of TACE group were 68.9%,46.2% and 16.4%.Conclusion RFA for liver cancer has higher local relief effect,and it has better effect than TACE.