肺癌患者化疗所致呕吐的药物预防方案

Drug Prevention Program for Chemotherapy-induced Vomiting in Lung Cancer Patients

目的研究肺癌患者化疗致呕吐的药物预防方案。方法 100例肺癌患者随机分为干预组与对照组;干预组与化疗组同时开始规定方案治疗、2组均于化疗当日开始使用5-HT3受体拮抗剂,至化疗结束。干预1组:"胃复安+苯海拉明+麻仁软胶囊+甲羟孕酮";干预2组单独给药"胃复安"。对照组:昂丹司琼。采用秩和检验比较干预及对照组的控制呕吐疗效,并对不同亚组进行两两比较。结果干预组与对照组的控制呕吐有效率差异具有统计学意义(P<0.05)。控制呕吐有效率,干预1组优于干预2组(P=0.015)。经χ2检验,干预组与对照组化疗前后体力评分(PS评分)变化的差异有统计学意义(P<0.001)。结论胃复安+苯海拉明+麻仁软胶囊+甲羟孕酮方案可减轻化疗致呕吐、提高患者生活质量。

Objective To study the drug prevention program for chemotherapy-induced vomiting in lung cancer patients.Methods 100 cases of lung cancer were randomly assigned into the intervention group and the control group. The intervention group and the chemotherapy group began prescribed regimen,both groups received 5-HT3 receptor antagonist chemotherapy that day,to the end of chemotherapy. Intervention Group 1 received metoclopramide + diphenhydramine + maren soft capsule + medroxyprogesterone,intervention group 2 was administered alone metoclopramide. The control group received ondansetron. Control vomiting rank sum test was used to compare the efficacy of the intervention group and the control groups,and different subgroups pairwise comparison was analyzed. Results Control vomiting efficiency between the intervention group and the control group had statistically significant difference( P < 0. 05). Control vomiting efficiency of intervention group 1 was superior to the intervention group 2( P = 0. 015). By χ2test,the difference between the intervention group and the control group before and after chemotherapy in change of physical score( PS score) was statistically significant( P < 0. 001). Conclusion Metoclopramide + diphenhydramine + maren soft capsule + medroxyprogesterone can reduce chemotherapy-induced vomiting,and improve the quality of life of patients.