肿瘤周边区微淋巴管密度对子宫内膜癌患者生存状况的影响

Influence of Peritumoral Micro-lymphatic Vessel Density on Prognosis of Patients with Endometrial Carcinoma

目的探讨肿瘤周边区微淋巴管密度对子宫内膜癌患者生存状况的影响。方法选取子宫内膜癌患者115例,采用免疫组化SP法检测LYVE-1、HIF-1α、VEGF-C的表达水平,低倍镜下分别对子宫内膜癌组织肿瘤边缘(PLVD)和中心区阳性淋巴管密集区域(I-LVD)。结果 P-LVD与肿瘤分化程度、FIGO分期和淋巴结转移是否有关(P<0.05),I-LVD与所有参数无关(P>0.05);HIF-1α和VEGF-C阳性表达率分别为76.19%和52.38%;P-LVD、病理类型、FIGO分期为子宫内膜癌患者预后的独立危险因素(P<0.05)。结论 HIF-1α和VEGF-C在子宫内膜癌患者中表达较高;影响子宫内膜癌患者的独立危险因素有P-LVD、病理类型和FIGO分期。

Objective To investigate the influence of peritumoral micro-lymphatic vessel density on prognosis of endometrial carcinoma. Methods 115 cases of endometrial carcinoma were selected. The level of LYVE-1,HIF-1α and VEGF-C were determined using the immunohistochemical SP method. Peritumoral lymphatic vessel density( P-LVD) and intratumoral lymphatic vessel density( I-LVD) were observed by low magnification microscope. Results P-LVD was closely associated with the degree of differentiation,FIGO staging,with or without lymph node metastasis,and I-LVD was not related with any parameters. The positive rates of HIF-1α and VEGF-C were 76. 19% and 52. 38%,respectively. P-LVD,pathological type and FIGO staging were independent risk factor for prognosis( P < 0. 05). Conclusion HIF-1αand VEGF-C are highly-expressed in endometrial carcinoma,FIGO staging,with or without lympho node metastasis; P-LVD,pathological type and FIGO staging are independent risk factor for prognosis.