放疗与单纯化疗对小细胞肺癌的疗效及安全性

Efficacy and Safety of Radiation Therapy and Chemotherapy for Small Cell Lung Cancer

目的探讨与比较放疗与单纯化疗治疗小细胞肺癌的疗效与安全性。方法将180例小细胞肺癌患者随机分为放疗组与化疗组,每组各90例,放疗组采用常规放射治疗与三维适形放射治疗,化疗组采用EP、CE、CAO化疗方案,观察与比较两组患者的临床治疗效果与不良反应发生状况。结果放疗组治疗总有效率(RR)与化疗组基本接近,放疗组疾病控制率(DCR)稍高于化疗组,均无统计学差异(χ2=0.927,χ2=1.327,P>0.05),放疗组1年生存例数、2年生存例数、3年生存例数均显著多于化疗组,组间具统计学差异(P<0.05),组间各不良反应发生率无统计学差异(P<0.05)。结论放射治疗与单纯化疗的治疗总有效率和疾病控制率基本一致,两组患者的不良反应轻,均可耐受,而放射治疗较单纯化疗可延长小细胞肺癌患者的生存期及提高生存率。

Objective To investigate the efficacy and safety of radiation therapy and chemotherapy for small cell lung cancer. Methods 180 small cell lung cancer patients were randomly divided into radiotherapy group and chemotherapy group,each with 90 cases,radiotherapy group received conventional radiotherapy and three-dimensional conformal radiation therapy,chemotherapy group received EP,CE,CAO chemotherapy,clinical effect and adverse reactions of the 2 groups were observed and compared. Results The total effective rate of radiotherapy group was close to that of the chemotherapy group,and disease control rate( DCR) of radiotherapy group was slightly higher than that of the chemotherapy group,there was no significant difference( χ2=0. 927,χ2= 1. 327,P > 0. 05),1-,2-,3-year survival rates in radiotherapy group was significantly higher than those of the chemotherapy group,there was significant difference between the 2 groups( P < 0. 05),incidence of adverse reactions between the 2groups had no significant difference( P > 0. 05). Conclusion Total efficiency and disease control rate of chemotherapy and radiotherapy treatment basically are same,adverse reactions in the 2 groups are mild and can be tolerated,and radiation therapy can prolong survival time and survival rate of patients with small cell lung cancer.