血清肿瘤标志物水平改变对胃癌患者化疗效果的评价价值

Evaluation of Serum Tumor Markers on the Effect of Chemotherapy for Gastric Cancer

目的探讨血清肿瘤标志物水平改变对胃癌患者化疗效果的评价作用。方法选取95例胃癌患者为研究对象,均予化疗。在治疗前后抽取静脉血,检测AFP、CEA、CA19-9、CA125、CA72-4,观察化疗前后以上指标水平改变和疗效之间的相关性。结果 95例患者中完全缓解有9例(9.47%),部分缓解有15例(15.79%),稳定有40例(42.10%),进展有31例(32.63%)。完全缓解和部分缓解患者的血清,指标AFP、CEA、CA19-9、CA125、CA72-4水平化疗前后比较,差异有统计学意义(P<0.05);稳定患者的血清,指标AFP、CEA、CA19-9、CA125、CA72-4水平化疗前后比较,差异无统计学意义(P>0.05);进展患者的血清,指标AFP、CEA、CA19-9、CA125、CA72-4水平化疗后较化疗前升高,化疗前后比较差异有统计学意义(P<0.05)。结论血清肿瘤标志物水平高低能反映出胃癌化疗疗效情况。

Objective To investigate the value of serum tumor markers on the effect of chemotherapy for gastric cancer patients. Methods 95 cases of gastric cancer patients received chemotherapy. AFP,CEA,CA19-9,CA125,CA72-4 in venous blood before and after treatment were detected. Change of these indicators and its correlation with efficacy were observed before and after chemotherapy. Results In the 95 patients,there had 9 cases( 9. 47%) of complete remission,15 cases( 15. 79%) of partial remission,40 cases( 42. 10%) of stable disease,31 cases( 32. 63%) of progression. AFP,CEA,CA19-9,CA125,CA72-4in complete remission and partial remission before and after chemotherapy had significant difference( P < 0. 05); AFP,CEA,CA19-9,CA125,CA72-4 in stable disease before and after chemotherapy had no statistically significant difference( P > 0. 05),while AFP,CEA,CA19-9,CA125,CA72-4 in progressive cases increased after chemotherapy,there had significant difference( P <0. 05). Conclusion Serum tumor markers AFP,CEA,CA19-9,CA125,CA72-4 can reflect the effect of chemotherapy for gastric cancer.