CMNa、GEMOX方案介入化疗局部复发鼻咽癌的临床观察

Clinical Observation of GEMOX and CMNa Regimen Intervention for Local Recurrent Nasopharyngeal Carcinoma

目的探讨CMNa、GEMOX方案介入化学治疗局部复发鼻咽癌的效果。方法选取2008年11月至2013年11月期间收治的30例局部复发鼻咽癌患者,随机分成观察组与对照组。对照组采用化疗方法,观察组在对照组基础上采用CMNa、GEMOX方案,比较2组患者的临床效果和急性不良反应。结果观察组局部复发鼻咽癌患者治疗结束时的RR率明显高于对照组(χ2=4.36,P=0.011<0.05);治疗3个月后,观察组的RR率明显高于对照组(χ2=5.68,P=0.023<0.05)。2组局部复发鼻咽癌患者的急性不良反应主要表现在皮肤反应、胃肠道反应、白细胞减少、贫血以及血小板减少等方面,但2组患者的急性不良反应差异无统计学意义。结论 CMNa、GEMOX方案介入化学治疗局部复发鼻咽癌具有较高的增敏性和临床疗效,急性不良反应不大,值得在临床上推广应用。

Objective To explore the clinical observation of GEMOX and CMNa regimen intervention for local recurrent nasopharyngeal carcinoma. Methods 30 cases of patients with local recurrent nasopharyngeal carcinoma were randomly divided into the observation group and the control group,the control group received chemotherapy,the observation group were given CMNa and GEMOX program based on the control group. The clinical effect and acute toxicities of the 2 groups were compared. Results The RR rate of the local recurrence of nasopharyngeal carcinoma patients in the observation group was significantly higher than that of the control group( χ2= 4. 36,P = 0. 011 < 0. 05). And 3 months after the treatment,the RR rate of the observation group was significantly higher than that of the control group( χ2= 5. 68,P = 0. 023 < 0. 05). Acute toxicities of the 2 groups of patients with locally recurrent nasopharyngeal carcinoma were mainly skin reactions,gastrointestinal reactions,leukopenia,anemia and thrombocytopenia,etc.,but the acute toxicities between the 2 groups was not statistically significant. Conclusion GEMOX and CMNa regimen intervention for local recurrent nasopharyngeal carcinoma has high sensitization and clinical efficacy,and the acute toxicity is less,and it is worthy of clinical application.