紫杉醇脂质体用于宫颈癌患者术后放化疗中的疗效观察

Observation of Curative Effect of Paclitaxel Liposome in Chemoradiotherapy for Patients with Cervical Cancer after Operation

目的探讨紫杉醇脂质体用于宫颈癌患者术后放化疗中的疗效以及对患者生存质量、免疫功能、中性粒细胞和血红蛋白水平的影响。方法 82例宫颈癌患者随机分成对照组和观察组,各41例。对照组:接受常规放疗治疗和DP化疗方案治疗。观察组:在接受常规放疗治疗和DP化疗方案治疗的同时应用紫杉醇脂质体治疗。结果观察组总有效率为95.12%,高于对照组的80.49%,差异具有统计学意义(P<0.05)。治疗后,观察组患者CD3+、CD4+水平高于对照组患者CD3+、CD4+水平,差异具有统计学意义(P<0.01)。治疗后,观察组患者CD8+水平低于对照组患者CD8+水平,差异具有统计学意义(P<0.01)。治疗后,观察组患者Ig G(8.42±1.75)g/L、Ig M(1.99±0.38)g/L、Ig A(2.32±0.41)g/L都高于对照组患者Ig G(7.01±1.33)g/L、Ig M(1.23±0.30)g/L、Ig A(1.39±0.33)g/L,差异均有统计学意义(P<0.01)。治疗后,观察组患者外周血中性粒细胞和血红蛋白水平都高于对照组患者外周血中性粒细胞和血红蛋白水平,差异均有统计学意义(P<0.01)。治疗后,观察组患者症状/副作用(30.1±7.2)分、躯体(59.3±9.8)分、心理(52.3±8.5)分、社会(33.3±5.5)分,都高于对照组患者症状/副作用(24.0±6.5)分、躯体(49.8±9.0)分、心理(44.0±7.2)分、社会(26.0±4.2)分,差异均有统计学意义(P<0.01)。结论紫杉醇脂质体应用于宫颈癌术后的化疗治疗效果显著,能够显著提高患者的免疫抵抗力、改善患者的生存质量。

Objective To study the efficacy of paclitaxel liposome in chemoradiotherapy for patients with cervical cancer after operation,and its effect on life quality,immunity,neutrophil and hemoglobin level. Methods 82 cases of cervical cancer patients were randomly divided into the control group and the observation group,41 cases in each. The control group received conventional radiotherapy and DP chemotherapy. The observation group received radiotherapy and DP chemotherapy as well as paclitaxel liposome. Results The total effective rate was 95. 12% in the observation group,which was higher than 80. 49% in the control group,there had statistically significant difference( P < 0. 05). After treatment,CD3+,CD4+level in the observation group were higher than those of the control group,there had significant difference( P < 0. 01). After treatment,the level of CD8+in the observation group was lower than that of the control group,there had significant difference( P < 0. 01). After treatment,Ig G was( 8. 42 ± 1. 75) g/L,Ig M was( 1. 99 ± 0. 38) g/L,Ig A was( 2. 32 ± 0. 41) g/L in the observation group,which were higher than Ig G( 7. 01 ± 1. 33) g / L,Ig M( 1. 23 ± 0. 30) g / L,Ig A( 1. 39 ± 0. 33) g / L in the control group,the difference was statistically significant( P < 0. 01). After treatment,hemoglobin levels in peripheral blood leukocytes,neutral in the observation group were higher than those of the control group,the difference was statistically significant( P < 0. 01). After treatment,symptoms / side effects was( 30. 1 ± 7. 2),somatic was( 59. 3 ± 9. 8),psychology was( 52. 3 ± 8. 5),social was( 33. 3 ± 5. 5) in the observation group were higher than symptoms / side effects( 24. 0 ± 6. 5),somatic( 49. 8 ± 9. 0),psychology( 44. 0 ± 7. 2),social( 26. 0 ± 4. 2) in the control group,the difference was statistically significant( P < 0. 01). Conclusion Paclitaxel liposome in chemoradiotherapy for patients with cervical cancer after operation is effective,it can significantly improve the immune resistance and quality of life.