薏苡仁甘油三酯联合放化同步治疗无手术指征食管癌患者的临床研究

Clinical Study of Semen Coicis Triglycerides Combined with Synchronous Treatment of Radiotherapy and Chemotherapy for Esophagus Cancer Patients without Surgical Indications

目的探讨薏苡仁甘油三酯联合放化同步治疗无手术指征食管癌患者的临床应用效果。方法选取无手术指征的食管癌患者70例,等分为两组,分别采用薏苡仁甘油三酯联合放化同步治疗(K组)及单纯放化疗联合方案(H组),比较两组疗效及不良反应情况。结果治疗4个疗程后,总有效率K组高于H组,但无统计学意义(P>0.05),Th-17频数比例、CD4+CD25+Tregs频数比例、IL-1、IL-6及TNF-ɑ含量H组均明显高于K组(P<0.05)。不良反应K组明显少于H组(P<0.05),不良反应严重程度K组与H组比较无统计学差异(P>0.05)。结论薏苡仁甘油三酯联合放化同步治疗无手术指征食管癌患者较单纯应用放化疗疗效更好,且能够较好地保护患者免疫功能,因而可以作为无法手术食管癌患者保守治疗的选择之一。

Objective To investigate the curative effect of semen coicis triglycerides combined with synchronous treatment of radiotherapy and chemotherapy for esophagus cancer patients without surgical indications. Methods 70 cases of esophagus cancer patients without surgical indications were randomly divided into 2 group,each with 35 cases. Group K received semen coicis triglycerides combined with synchronous treatment of radiotherapy and chemotherapy,and group H received synchronous treatment of radiotherapy and chemotherapy. The curative effects and adverse reactions of the 2 groups were compared. Results After 4 courses of treatment,the total effective rate of group K was higher than that of group H,but there had no statistical difference( P > 0. 05). The levels of Th-17 frequency,CD4 + CD25 + Tregs frequency,IL-1,IL-6 and TNF-ɑ of group H were significantly higher than those of group K( P < 0. 05). Adverse reactions of group K was significantly less than that of group H( P <0. 05),but the degree of adverse reactions between the 2 groups had no statistical difference( P > 0. 05). Conclusion Semen coicis triglycerides combined with synchronous treatment of radiotherapy and chemotherapy for esophagus cancer patients without the indications has better effects than synchronous treatment of radiotherapy and chemotherapy,and it can efficiently protect the patient’s immune function. It can be one of the conservative treatment options for esophageal cancer patients without surgical indications.