肺癌化疗患者发生静脉血栓栓塞症的相关因素研究

Study of Related Factors of Venous Thromboembolism in Lung Cancer Patients Treated with Chemotherapy

目的探讨与分析肺癌化疗患者发生静脉血栓栓塞症的相关影响因素。方法回顾性分析化疗后并发静脉血栓栓塞症的150例肺癌患者的临床资料,对可能的有关因素进行单因素分析,将有统计学意义的变量再引入Logistic回归模型进行多因素分析。结果经单因素分析,年龄、D-二聚体水平、心血管疾病以及血黏稠度水平对静脉血栓栓塞症(VTE)发生的影响有统计学意义(P均<0.05),多因素Logistic回归分析结果显示,血黏稠度水平是影响肺癌化疗患者发生静脉血栓栓塞症的主要因素(OR=10.620)。结论具有较高血黏稠度水平的肺癌化疗患者并发VTE的风险性大,对于高风险的患者应该采用规范性的血栓预防措施。

Objective To study the related factors of venous thromboembolism( VTE) in lung cancer patients treated with chemotherapy. Methods Clinical data of 150 cases of patients with lung cancer and VTE treated with chemotherapy were retrospectively analyzed. Potential related factors received single factor analysis,and logistical regression model was used to analyze all factors with statistical significance. Results Single factors analysis showed that ages,D-dimer level,cardiovascular diseases and effect of blood viscosity level had statistical significant influence on VTE( P < 0. 05). Multi-factor logistic regression analysis indicated that blood viscosity level was the main factor for VTE in lung cancer patients treated with chemotherapy( OR =10. 620). Conclusion Lung cancer patients with higher blood viscosity level has a high risk of suffering VTE,and patients with high risk of VTE should take standard preventive methods.