钼靶X线对乳腺癌的临床诊断价值及其与乳腺癌病理相关性的研究

Clinical Value of X-ray Mammography in the Diagnosis of Breast Cancer and its Correlation with Pathology

目的评估钼靶X线对浸润性导管乳腺癌的诊断价值及与其临床病理特征关系。方法回顾性分析231例乳腺癌患者的临床资料。采用Fisher精确检验,χ2检验,Spearman相关回归分析钼靶X线与乳腺癌临床病理特征的关系。结果 231例患者接受乳房X线检查,恶性钙化在人表皮生长因子受体2(HER2)阳性患者(P=0.001)或肿瘤直径>2 cm的乳腺癌患者中最常见(P=0.006)。钼靶X线多形型与p53阳性状态(P=0.039)及淋巴结转移(P=0.048)相关,而钼靶X线模糊非晶型与HER2受体阳性状态(P=0.026)相关。高表达Ki-67的肿瘤患者常见明显的肿块(P=0.002)。结论 X线特征与乳腺癌临床病理特征相关,相关性反映肿瘤的属性,并且可指导临床治疗。

Objective To evaluate the clinical value of X-ray mammography in the diagnosis of breast cancer and its correlation with clinicopathological features. Methods A retrospective analysis of clinical data of 231 cases of breast cancer were conducted. Fisher’s exact test,χ2test,Spearman regression analysis were used to detect the relationship between X-ray mammography and clinicopathological features of breast cancer. Results 231 patients received breast X-rays,malignant calcification was common in the human epidermal growth factor receptor 2( HER2)-positive patients( P = 0. 001) or breast cancer patients with tumor diameter > 2 cm( P = 0. 006). X-ray mammography pleomorphic type and p53-positive status( P = 0. 039) and lymph node metastasis( P = 0. 048) were correlated,while molybdenum target X-ray amorphous and vague HER2 receptor-positive status( P= 0. 026) were correlated. Patients with high expression of Ki-67 have common tumor mass( P = 0. 002). Conclusion X-ray features are associated with clinicopathological features of breast cancer,which reflect tumor properties,it can guide clinical treatment.