宫颈上皮内瘤变的临床病理与HPV感染的相关性

The Correlation of Clinical Pathological Features and HPV Infection in Cervical Intraepithelial Neoplasia

目的探讨宫颈上皮内瘤变的临床病理与HPV感染的相关性。方法对病理诊断为CINⅠ级及以上病变为组织病理学阳性患者(病变组)60例和宫颈正常为组织病理学阴性患者(正常组)20例都进行HPV感染情况的检测。结果在80例入选者中,HPV检测阳性48例,阳性率为60.0%。正常组HPV检测阳性率为20.0%(4/20),而病变组HPV阳性率为73.3%(44/60),2组差异有统计学意义(P<0.05)。随着宫颈病变级别的增加,HPV的总阳性率逐渐上升(P<0.05),其中宫颈原位癌的HPV阳性率为100.0%。在HPV检测阳性的48例患者中,单一感染30例,多重感染18例;其中HPV16阳性24例,合并HPV18阳性10例,HPV58阳性5例,其他9例。Spearman等级相关分析显示宫颈上皮内瘤变阳性情况与HPV检测阳性情况呈现明显正向相关性(γ=0.567,P<0.05)。结论宫颈上皮内瘤变多表现为HPV感染阳性,而随着病变级别的增加,HPV感染的阳性率逐渐上升,两者可互相影响,存在正向相关性。

Objective To investigate the correlation of clinical pathological features and HPV infection in cervical intraepithelial neoplasia. Methods 60 cases suspected cervical intraepithelial neoplasia( CIN) cases who were diagnosed to be grade CIN Ⅰ and more positive histopathological lesions( lesions group),and 20 cases normal cervical tissue pathology negative( normal group) were selected,and HPV infection in both groups were detected. Results There were 48 cases of HPV testing positive in the 80 cases,the positive rate was 60. 0%. In the normal group,the HPV testing positive were 4 cases,the positive rate was20. 0%; while lesions group were 60 cases,the HPV positive were 44 cases,the positive rate was 73. 3%,there were significant difference( P < 0. 05). With the increase of cervical lesions,HPV positive rate were gradually increased( P < 0. 05),the HPVpositive of cervical carcinoma in situ were 100. 0%. In HPV-positive 48 cases,single infection was 30 cases,18 cases of multiple infections in which HPV16 positive was 24 cases,10 cases was positive consolidation HPV18,HPV58 positive was 5 cases,the other were 9 cases. Spearman rank correlation analysis showed that CIN were significant positive correlated with the HPV positive( γ = 0. 567,P < 0. 05). Conclusion CIN is mainly positive HPV infection,and with the increase in the level of the lesion,the positive rate of HPV infection gradually increase,both of which may influence each other,there is a positive correlation.