结肠癌组织中CD151和整合素α3的表达及其临床价值

Clinical Value of CD151 and Integrin α3 in Patients with Colon Cancer

目的通过检测结肠癌组织中CD151和整合素α3的表达情况来探讨其临床应用价值。方法选取60例结肠炎患者和经手术组织病理检查诊断为结肠癌的120例患者作为本次研究对象,分别应用免疫组化SP法检测受检对象组织中CD151和整合素α3表达情况。结果结肠炎组织中无CD151和整合素α3表达,而结肠癌组织中CD151和整合素α3阳性表达率分别为88. 33%(106/120)、85. 83%(103/120),两者差异均有统计学意义(χ~2=128. 919、120. 389,P=0. 00、0. 00)。不同年龄、性别、组织学分型、肿瘤大小及分化程度结肠癌组织CD151和整合素α3表达阳性率比较,P> 0. 05;而存在淋巴结转移、远处转移的结肠癌组织CD151和整合素α3阳性表达率明显高于无淋巴结转移、无远处转移组织,P <0. 05。在结肠癌组织中,经Spearman等级相关性分析,CD151和整合素α3阳性表达在结肠癌患者中呈正相关性(γ=0. 5123,P=0. 000)。结论通过检测结肠癌患者CD151和整合素α3阳性表达情况可有利于临床医师判断患者病情状况,同时为临床评估患者预后及制定治疗方案提供参考。

Objective The clinical value of CD151 and integrinα3 expression in colon cancer patients was explored.Methods 60 patients with colitis treated in our hospital from July 2016 to August 2017 and 120 cases diagnosed as colon cancer by histopathological examination were selected as the study subjects and immunohistochemical SP method was used to detect the subjects CD151 and integrinα3 expression in tissues.Results The positive rates of CD151 and integrinα3 in colon cancer tissues were 88.33%(106/120),85.83%(103/120),χ~2=128.919 and 120.389,respectively,P=0.00,0.00.The positive rates of CD151 and integrinα3 in colorectal cancer tissues at different ages,genders,histological types,tumor size and differentiation were significantly higher than those of normal controls(P>0.05).The positive rate of CD151 in colorectal cancer with lymph node metastasis was significantly higher than that without lymph node metastasis,P<0.05;The positive rate of CD151 expression in distant metastasis colon cancer was significantly higher than those without distant metastasis,P<0.05.The positive rate of integrinα3 in colon cancer with lymph node metastasis was significantly higher than that without lymph node metastasis,P<0.05;the positive rate of integrinα3 in distant metastasis colon cancer was significantly higher than that without distant metastasis(P<0.05).Colitis patients,CD151 and integrinα3 were negative expression,and colon cancer,CD151 and integrinα3 positive expression rates were 88.33%,85.83%;Spearman rank correlation analysis,CD151 and integrinα3-positive Expression was positively correlated with colon cancer patients,γ=0.5123,P=0.000.Conclusion By detecting the positive expression of CD151 and integrinα3 in colon cancer patients,it is helpful for clinicians to judge the patient’s condition,and provide the guiding value for clinical prognosis evaluation and treatment planning.