结直肠癌术前不同CEA水平对患者预后及复发转移的影响

The Influence of Different CEA Level at Colorectal Cancer Preoperative on Prognosis and Metastasis

目的探讨结直肠癌术前不同CEA水平对患者预后及复发转移的影响。方法选择97例结直肠癌患者,根据术前CEA水平,将97例患者分为观察组(CEA≥5 ng/ml,48例)及对照组(CEA <5 ng/ml,49例),对比2组患者术后1年、3年、5年的生存率及总生存期,对比2组患者术后5年的复发转移率,分析结肠癌患者术后总生存期的影响因素。结果观察组术后1年、3年、5年的生存率及总生存期均明显低于对照组(P均<0. 05)。观察组术后5年总复发转移率明显高于对照组(P <0. 05)。CEA是影响结肠癌患者术后总生存期的危险因素。结论结直肠癌术前CEA≥5 ng/ml是影响患者术后预后及复发转移的独立危险因素。对于CEA≥5 ng/ml者,应及时预防,以改善疾病转归及预后。

Objective To investigate the influence of different CEA level at colorectal cancer preoperative on prognosis and metastasis.Methods 97 cases with colorectal cancer were chosen and divided into the observation group(CEA≥5 ng/ml,48 cases)and control group(CEA<5 ng/ml,49 cases),the survival rate after surgery for 1 year,3 years and 5 years and the overall survival of two groups were compared,the recurrence rate after surgery for 5 years of two groups were compared,the influence factors of postoperative survival of colon cancer patients were analyzed.Results The survival rate of observation group after surgery for 1 year,3 years and 5 years and overall survival were lower than control group,the 5 years recurrence rate of observation after surgery for 5 years were higher than control grou.CEA was the risk factor influence on postoperative survival of colon cancer patients.Conclusion Preoperative CEA≥5 ng/ml is an independent risk factor for prognosis and recurrence and metastasis of colorectal cancer.For CEA≥5 ng/ml,it should be prevented in time to improve the outcome and prognosis of the disease.