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绿原酸磷脂复合物固体分散体的体外溶出和药动学研究 被引量:6

Dissolution behavior in vitro and pharmacokinetic profile of chlorogenic acid phospholipid complex solid dispersion in rats
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摘要 为研究绿原酸磷脂复合物固体分散体(CA-PC-SD)的体外溶出以及体内药动学规律,采用HPLC法考察CAPC-SD的体外溶出,大鼠灌胃后测定其血药浓度,并采用DAS 2.0软件分析计算药动学参数。结果显示:CA-PC-SD显著改善绿原酸磷脂复合物(CA-PC)的溶出效果,相较于原料药(CA)其相对生物利用度提高2.12倍。表明CA-PCSD能显著改善CA-PC的体外溶出特性以及CA的口服生物利用率。 To study the chlorogenic acid phospholipid complex solid dispersion(CA-PC-SD)dissolution behavior of CA in vitro and pharmacokinetics of CA in the rats. The dissolution behavior of CA-PC-SD in vitro and plasma concentration of CA in rats was determined by HPLC. The pharmacokinetic parameters were estimated by DAS VER2.0 software. Results show that in vitro dissolution of CA-PC-SD is obviously greater than CA-PC. The oral bioavailability of CA-PC-SD is increased 2.12 times than CA. CA-PC-SD can significantly improve dissolution characters of CA-PC in vitro as well as the oral bioavailability of CA in rats.
出处 《中国测试》 北大核心 2015年第1期54-57,共4页 China Measurement & Test
关键词 绿原酸 磷脂复合物 固体分散体 溶出度 药动学 口服生物利用度 chlorogenic acid phospholipid complex solid dispersion dissolution pharmacokinetics oral bioavailability
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  • 1谢沐风.改善溶出度评价方法,提高固体药物制剂水平[J].中国医药工业杂志,2005,36(7):447-451. 被引量:125
  • 2孙秋艳,刘艳,汪茜,刘洁,包旭.绿原酸对Lewis肺癌小鼠及人A549肺癌的实验研究[J].华西药学杂志,2010,25(5):536-538. 被引量:22
  • 3马希汉,张康健,尉芹,王蓝.从杜仲叶中提取绿原酸纯品的研究[J].西北林学院学报,1996,11(2):58-60. 被引量:32
  • 4林丽洋,贺英菊,陈艳,莫毅,闫根全.绿原酸-β-环糊精包合物的制备及验证[J].天津药学,2006,18(5):25-27. 被引量:7
  • 5王天然 邢善田.淫羊藿总黄酮促进免疫功能的实验[J].中成药研究,1987,9(2):27-27.
  • 6梁文权,方晓玲,邓树海,程刚等.生物药剂学与药物动力学第二版[M].北京.人民卫生出版社:328-346.
  • 7DORRELL D G.Chlorogemc acid content of meal from cultivatial sunflower[J].Crop science, 1976(16) : 422-426.
  • 8BATZIAS GC, DELLS GA. Reversed-phase liquid chromatographic method with fluorescence detection for the simultaneous delerminalion of albendazole sulphoxide, albendazole sulphone and albendazole 2-aminosulphone in sheep plasma[J].J Chromatogr B Artalyt Techrtol Biomed Life Sci,2004,805 (2) :267 -274.
  • 9CHIAP P,EVRARD B,BIMAZUBUTE MA,et al. Determination of albendazole and its main metabolites in ovine plasma by liquid chromatography with dialysis as integrated sample preparation technique[J].J Chromatogr A,2000:870(1 -2):121-134.
  • 10梁文权.生物药剂学与药物动力学[M].第1版.北京:人民卫生出版社,1998:241-252.

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