摘要
为研究绿原酸磷脂复合物固体分散体(CA-PC-SD)的体外溶出以及体内药动学规律,采用HPLC法考察CAPC-SD的体外溶出,大鼠灌胃后测定其血药浓度,并采用DAS 2.0软件分析计算药动学参数。结果显示:CA-PC-SD显著改善绿原酸磷脂复合物(CA-PC)的溶出效果,相较于原料药(CA)其相对生物利用度提高2.12倍。表明CA-PCSD能显著改善CA-PC的体外溶出特性以及CA的口服生物利用率。
To study the chlorogenic acid phospholipid complex solid dispersion(CA-PC-SD)dissolution behavior of CA in vitro and pharmacokinetics of CA in the rats. The dissolution behavior of CA-PC-SD in vitro and plasma concentration of CA in rats was determined by HPLC. The pharmacokinetic parameters were estimated by DAS VER2.0 software. Results show that in vitro dissolution of CA-PC-SD is obviously greater than CA-PC. The oral bioavailability of CA-PC-SD is increased 2.12 times than CA. CA-PC-SD can significantly improve dissolution characters of CA-PC in vitro as well as the oral bioavailability of CA in rats.
出处
《中国测试》
北大核心
2015年第1期54-57,共4页
China Measurement & Test
关键词
绿原酸
磷脂复合物
固体分散体
溶出度
药动学
口服生物利用度
chlorogenic acid
phospholipid complex
solid dispersion
dissolution
pharmacokinetics
oral bioavailability