摘要
该文采用核磁共振的氢谱、碳谱和相关谱技术,同时结合质谱和红外光谱等技术,对DX-1002的化学结构进行解析。结果表明DX-1002的氢谱(1H-NMR)和碳谱(13C-NMR)各个化学位移值与DX-1002各个氢原子和碳原子的归属一致;结合同核化学位移相关谱(g COSY)、异核多量子关系谱(g HMQC)、核欧佛豪瑟效应频谱(NOESY)等综合分析,确定分子的空间结构;然后综合质谱和红外光谱确定DX-1002的化学结构为(E)-3-(3″-羟基-4″-甲氧苯基)-2-(3′,4′,5′-三甲氧基苯基)丙烯酸正丁铵盐。
The spectrums of1H-NMR and13C-NMR and others in combination with MS and IR were applied to analyze the chemical structure of tumor angiogenesis inhibitor DX-1002. Experimental results indicate that the chemical shifts of the1H-NMR and13C-NMR are consistent with the hydrogen atoms and carbon atoms of DX-1002. The spatial structure of molecules was determined on the basis of g COSY,g HMQC and NOESY. And then the chemical structure of DX-1002 was confirmed via mass spectrum and infrared spectrum to be(E)-3-(3″-hydroxy-4″-methoxyl phenyl)-2-(3′,4′,5′-triethoxyphenyl) N-butyl acrylate ammonium salt.
出处
《中国测试》
北大核心
2015年第11期55-58,共4页
China Measurement & Test
基金
东莞市引进创新创业领军人(201476815)
