摘要
目的分析比较3种不同麻醉剂对长爪沙鼠的麻醉效果。方法成年长爪沙鼠分为3组,分别腹腔注射水合氯醛、乌拉坦和戊巴比妥生理盐水溶液,观察麻醉诱导时间、麻醉期、苏醒时间及心率和呼吸变化,并与大、小鼠进行比较。结果长爪沙鼠在注射水合氯醛后麻醉保持时间最长,而乌拉坦最短。水合氯醛对呼吸和心跳的抑制能力较弱于乌拉坦和戊巴比妥。除了乌拉坦,其余两种药物对长爪沙鼠的麻醉时间均较大,小鼠更长一些。结论3种麻醉药对长爪沙鼠的麻醉效果明显不同,对其呼吸和心跳频率的影响也有差别,可以根据不同的实验要求选用这三种麻醉剂。相对于大、小鼠来说,长爪沙鼠对3种麻醉剂都更敏感。
Objective To observe and analyze the effects of three kinds of common anaethetic drugs. Method The adult Mongolian gerbils were divided into three groups and injected with the physiological saline solution of chloral hydrate,urethane, ornembutal by intraperitoneal injection, respectively. Then induction time, duration and recovery time of anesthesia,and heart rates and respiratory changes after anesthesia were measured. The same experiments were also carried out in rats and mice. Result The duration of chloral hydrate is the longest,and that of urethane is the shortest. Chloral hydrate inhibited respiratory and heart rates less than urethane and nembutal.Relatively to urethane,the anaethetic duration of the other two drugs in gerbils were longer than that in rats and mice. Conclusion The anaethetic effects of three kinds of drugs are obviously different in gerbils. The influence in heart rates and respiratory changes is also different. We should choose these drugs according to the requirement of experiments. Compared to rats and mice,Mongolian gerbils are more sensitive to these drugs.
出处
《实验动物科学》
2015年第5期43-46,共4页
Laboratory Animal Science
基金
国家自然基金面上项目(No:31272393
31373373)
国家自然科学基金青年项目(No:31402027)
关键词
水合氯醛
乌拉坦
戊巴比妥
长爪沙鼠
麻醉
chloral hydrate
urethane
nembutal
Mongolian gerbil
anesthesia
