抗艾滋病毒治疗的药物联用模式

Combination modes of antiretroviral drugs in anti-HIV treatments

抗艾滋病毒(HIV)治疗就是联用不同的抗HIV药物以达到抗病毒作用最大化。新型抗病毒药物的出现为抗HIV治疗提供了新的选择,且许多新的药物联用模式的有效性已被临床证实。目前,抗HIV治疗的药物联用模式主要是以双核苷类药物为基础,再联用非核苷类药物(依非韦仑)、蛋白酶抑制剂或整合酶抑制剂。美国2011年的抗病毒指南对抗HIV治疗的药物联用模式进行了更新,本文予于介绍以供国内临床医师参考。

Antiretroviral therapy(ART) is the most important and effective therapy for HIV/AIDS,which combines the different antiretroviral drugs to increase the antiretroviral effects.The new antiretroviral drugs have provided more choices for HIV/AIDS patients,and the effects of new drug combination modes have been confirmed through clinical trials.The current combination modes are based on the combination of two nucleoside reverse transcriptase inhibitors(NRTI) and dual NRTIs are commonly used in combination with a non-nucleoside reverse transcriptase inhibitor,a protease inhibitor(usually boosted with ritonavir),or an integrase inhibitor.The 2011 USA guidelines updated the initial combination regimen.This review introduces the combination modes of antiretroviral drugs in anti-HIV treatment,which can help guide ART in clinical practice.