抗反转录病毒治疗及机会感染治疗中的药物相互作用

Drug interactions in antiretroviral therapy and treatment for occasional infections

目前有30余种药物用于艾滋病毒感染治疗。3种及以上抗病毒药物联合应用显著提高了抗反转录病毒治疗的疗效,但也存在多种药物相互作用。同时,艾滋病患者常因机会感染接受治疗,而抗感染药物,尤其是抗结核、抗真菌药物的使用会使药物相互作用更加复杂。药物相互作用可能导致治疗疗效下降和(或)增加不良反应风险。本文主要介绍抗反转录病毒治疗和机会感染治疗中的重要药物相互作用以及与此有关的配伍禁忌和剂量调整。

More than 30 kinds of drugs are currently used to treat human immunodeficiency virus-1 infection.Combination therapy of 3 or more such drugs has greatly improved antiretroviral efficacy,which can lead to some multiple drug interactions.Antibiotics,especially anti-tubercular agents and antifungal agents are commonly used in patients with HIV/AIDS so as to complicate the drug interactions in this population.Drug interactions might lead to decrease therapeutic efficacy and increase risk of adverse events.This review introduces the major drug interactions in antiretroviral therapy and treatment for the occasional infections,as well as the dose adjustment and contraindication in combination therapy.