天麻素联合前列地尔治疗后循环缺血性眩晕的疗效观察

Posterior circulation ischemia treated with gastrodin and alprostadil

目的对比研究天麻素联合前列地尔以及单纯天麻素治疗后循环缺血导致的中枢性眩晕的临床疗效及不良反应。方法选取2010年10月至2012年10月在本院治疗的由于后循环缺血导致眩晕的患者95例,随机分为天麻素联合前列地尔组(治疗组)及天麻素治疗组(对照组),观察患者症状改善及不良反应情况。结果2组对眩晕的治疗都有明显疗效,但治疗组完全缓解率和总有效率均明显优于对照组(P<0.05),且完全缓解时间明显缩短(P<0.05),2组治疗前后椎动脉(VA)和基底动脉(BA)的平均血流速度(Vm)变化有显著性差异(P<0.05),且治疗组治疗后的血流改善优于对照组(P<0.05)。结论天麻素联合前列地尔治疗能明显改善后循环缺血性眩晕患者的临床症状,并能改善椎基底动脉的血流,值得临床推广。

Objective To compare the clinical efficacy and adverse reactions of the therapy of gastrodin combined with alprostadil and gastrodin alone on central vertigo caused by posterior circulation ischemia.Methods Ninety-five pa-tients with vertigo from October 2010 to October 2012 due to posterior circulation ischemia were randomly divided into gast-rodin combined with alprostadil group(treatment group) and gastrodin alone treatment group(control group).The im-provement of the symptoms and the adverse reactions were observed.Results The vertigo was significantly improved in the two groups.The complete remission rate and total effective rate in treatment group were significantly higher than those in control group(P < 0.05).The average flow velocity(Vm) of vertebral artery(VA) and basilar artery(BA) were changed significantly after treatment in two groups(P < 0.05),and more significantly in treatment group than those in con-trol group(P < 0.05).Conclusions Gastrodin combine alprostadil therapy could relieve the clinical symptoms of verti-go caused by posterior circulation ischemia,and also could improve the vertebral-basilar artery blood flow.