非空腹甘油三酯/高密度脂蛋白胆固醇比值对经皮冠状动脉介入治疗术后他汀治疗病人心血管事件的影响

Effect of non-fasting triglyceride/high-density lipoprotein cholesterol ratio on cardiovascular events in patients undergoing statin therapy after percutaneous coronary intervention

目的探讨非空腹甘油三酯/高密度脂蛋白胆固醇(TG/HDL-C)比值对经皮冠状动脉介入治疗(PCI)术后接受他汀治疗病人心血管事件的影响。方法入组1170例因急性冠状动脉综合征或稳定型心绞痛成功行PCI治疗的病人,术后长期应用他汀类药物。根据病人PCI术后3个月的非空腹TG/HDL-C比值将其分为组1(TG/HDL-C≤2)、组2(2<TG/HDL-C<3. 5)和组3(TG/HDL-C≥3. 5) 3组,每组各390例,并统计PCI术后5年内病人主要不良心血管事件(MACE)的发生率。结果 Kaplan-Meier曲线分析显示:组3病人的MACE发生率显著高于其他2组(P<0. 001)。Cox比例风险模型回归分析显示,非空腹TG/HDL-C比值是PCI术后接受他汀治疗病人发生MACE的独立危险因素。结论非空腹TG/HDL-C比值是PCI术后接受他汀治疗病人发生MACE最有价值的预测指标之一。

Objective To investigate the effect of non-fasting triglyceride/high-density lipoprotein cholesterol ratio on cardiovascular events in patients undergoing statin therapy after percutaneous coronary intervention( PCI). Methods A total of 1170 patients who underwent PCI for acute coronary syndrome or stable angina pectoris were enrolled in the study. All the patients have a long-term application of statins after surgery. According to the non-fasting TG/HDL-C ratio after 3 months of PCI,patients were divided into group 1( TG/HDL-C≤2),group 2( 2<TG/HDL-C<3. 5) and group 3( TG/HDL-C≥3. 5),with 390 cases in each group,and the incidence rate of major adverse cardiovascular events( MACE) within 5 years after PCI were analyzed. Results Kaplan-Meier curve analysis showed that the incidence rate of MACE in patients with higher TG/HDL-C ratio was significantly higher than that of other two groups( P< 0. 001). Cox proportional hazard model regression analysis showed that non-fasting TG/HDL-C ratio was significantly associated with the incidence rate of MACE in patients receiving statin therapy after PCI. Conclusions Non-fasting TG/HDL-C ratio is a valuable predictor of MACE in patients receiving statin therapy after PCI.