依达拉奉注射液联合盐酸普拉克索治疗老年血管性帕金森综合征的疗效及对氧化应激的影响

Curative efficacy of edaravone injection combined with pramipexole dihydrochloride in elderly patients with vascular Parkinson syndrome and its effects on oxidative stress

目的探讨依达拉奉注射液联合盐酸普拉克索治疗老年血管性帕金森综合征(VPS)临床疗效及对病人氧化应激的影响。方法将112例符合纳入标准的老年VPS病人随机分为对照组56例和观察组56例。常规治疗基础上,对照组给予盐酸普拉克索治疗,观察组在对照组基础上联合依达拉奉注射液治疗。比较2组病人临床疗效、帕金森病综合评分量表(UPDRS)评分、血清氧化应激指标水平及不良反应发生情况。结果经过治疗,观察组病人治疗总有效率高于对照组(87. 5%比71. 4%,P<0. 05)。治疗后,观察组病人UPDRS评分中的精神行为心境、日常生活活动、运动功能评分与对照组相比,均显著降低(P均<0. 05)。观察组病人血清丙二醛(MDA)水平低于对照组,超氧化物歧化酶(SOD)水平高于对照组(P均<0. 05)。结论依达拉奉注射液联合盐酸普拉克索在老年VPS中应用效果良好,能够有效改善病人临床症状,减轻氧化应激,且不良反应轻微。

Objective To investigate the curative efficacy of edaravone injection in combination with pramipexole dihydrochloride in the elderly patients with vascular Parkinson’s syndrome( VPS) and its effects on oxidative stress. Methods A total of 112 elderly patients with VPS were randomly divided into control group( n = 56) and observation group( n = 56). Based on conventional treatments,the control group was treated with pramipexole dihydrochloride,and the observation group was treated with edaravone injection in combination with pramipexole dihydrochloride. The curative efficacy, scores of unified Parkinson’s disease rating scale( UPDRS),levels of serum markers reflecting oxidative stress and adverse reactions were compared between the two groups. Results After treatment,the total therapeutic efficacy ratio in the observation group was statistically higher than that in the control group( 87. 5% vs 71. 4%,P<0. 05). In comparison with the control group after treatment,scores of mental,emotional and behavioral,activities of daily living and motor function in UPDRS were statistically lower in the observation group( all P<0. 05). In comparison with the control group after treatment,the observation group had lower level of malonaldehyde( MDA) and higher level of superoxide dismutase( SOD)( both P< 0. 05). During the treatment,there were no severe adverse reactions accurring in the two groups. And the incidence rate of adverse reactions in the control group and the observation group was 16. 1% and 21. 4% respectively with no statistical difference( P> 0. 05). Conclusions Edaravone injection in combination with pramipexole dihydrochloride has well application effect in the elderly patients with VPS,which can significantly improve clinical symptoms and alleviate oxidative stress with minor adverse reactions.