杏丁注射液治疗慢性肾脏病的疗效观察

Efficacy of Therapy with Ginkgo Leaf Extract and Diphyridamole Injection for Chronic Kidney Diseases.

目的观察杏丁注射液对慢性肾脏病患者的作用。方法对2004年6月至2005年10月山东省立医院肾脏内科住院的60例慢性肾脏病患者,其中Ⅲ期36例、Ⅳ期24例.给予1个疗程的杏丁注射液。观察临床症状是否改善,检测治疗前后患者的尿蛋白(ALB)、24 h 尿蛋白、血脂和肾功能的变化。结果治疗后28例(46.7%)患者临床症状明显得到改善,24例(40%)症状无明显改善但也无恶化,8例(13.3%)症状恶化。60例患者治疗后血脂(总胆固醇、甘油三脂)和24 h 尿蛋白定量明显得到降低。Ⅲ期36例患者经治疗后 ALB 和肾小球滤过率(GFR)明显上升,同时尿素氮(BUN)水平显著下降。而Ⅳ期患者上述参数无明显改变。结论杏丁注射液能够改善慢性肾脏病患者的临床症状和营养不良,延缓肾功能恶化的进展。

Objective To evaluate the effect s of Ginkgo Leaf Extract and diphyridamole injection on patient s with CKD.Methods 60 patients with CKD were made up with 36 cases in Ⅲ phase and 24 cases in Ⅳ phase.The patients with CKD were given Ginkgo Leaf Extract and diphyridamole injection,20 mL/d,for 15 days.The parameters of clini- cal condition,function of kidney,ALB and blood fat were observed before and after the therapy and the data were ana- lyzed.Results There were 28 cases that clinical condition was better; 24cases no difference; and 8 cases worse.The level of TC and TG were significantly decreased after the therapy,as well as the uric protein quality of 24 hours(P< 0.05).In the patients of Ⅲ phase there was significant increase in ALB and GFR,as parallel the level of BUN was de- creased(P<0.001).But there were no different in ALB,GRR and BUN in the patients of Ⅳ phase(P>0.05). Conclusion Essential treatment for CKD combined with Ginkgo Leaf Extract and diphyridamole injection can improve nutrition,delay the process of CKD and protect the renal function in patient s with Ⅲ phase.