阿托伐他汀对充血性心力衰竭患者心功能和C反应蛋白的影响

Effect of atorvastatin on cardiac function and C-reactive protein levels in patients with congestive heart failure.

目的探讨充血性心力衰竭(CHF)患者应用阿托伐他汀后对心功能和 C 反应蛋白(CRP)的影响及意义。方法对2003年2月至2005年8月河北医科大学第四医院心内科的62例 CHF 患者,随机分为两组,治疗组30例在常规治疗基础上加用阿托伐他汀,对照组32例只采用常规治疗。观察治疗前后两组患者的心功能和 CRP 变化。结果用药前两组患者心功能和 CRP 水平差异无统计学意义(P>0.05);加用阿托伐他汀的病人,心功能较对照组比较有明显改善(P<0.05);用药后两组病人血浆 CRP 均有明显降低(P<0.05),但加用阿托伐他汀组的病人,其血浆 CRP 较对照组比较又有明显降低(P<0.05)。结论 CHF 患者加用阿托伐他汀可明显改善心功能,降低 CRP。

Objective To investigate the effect of atorvastatin on cardiac function and C-reactive protein(CRP)lev- els in patients with congestive heart failure(CHF).Methods 62 patients with congestive heart failure were randomly included.Ejection fraction of patients were less than 0.35.30 patients received atorvastatin,32 patients were in control group.Cardiac function and CRP levels were compared between the two groups before and after treatment.Results There was no significant difference in cardiac function and CRP in two groups before treatment(P>0.05),whereas there was a significant difference in cardiac function in patients received atorvastatin(P<0.05).There was a signifi- cant decrease in CRP in two groups(P<0.05).Besides,CRP were significant decrease in patients received atorvasta- tin compaired with control group(P<0.05).Conclusion Patients received atorvastatin could improve cardiac func- tion and decrease the level of CRP.