p21^(WAF1)基因及p53蛋白在肺结核合并肺癌组织中的表达

The expression ofp21^(WAF1)gene and p53 protein in tuberculosis with lung cancer.

目的探讨细胞周期调节因子在肺结核合并肺癌中的价值。方法用免疫组织化学方法对101例肺结核合并肺癌组织 p21WAF1基因及 p53蛋白的表达进行检测。结果 101例肺结核合并肺癌中 p21^(WAF1)和p53蛋白阳性率分别是42.9%和64.1%,两者与肺结核合并肺癌的组织分化程度有关。结论同时检测p21^(WAF1)基因及 p53蛋白的表达情况,有助于判断肺结核合并肺癌的预后。

Objective To explore the role of cell cycle regulator in tuberculosis with lung cancer.Methods The ex- pression of p21^(WAF1)gene and p53 protein in 101 cases of tuberculosis with lung cancer have been detected by immunohis- toehemical method.Results total positive staining rate of p21^(WAF1)gene and p53 protein was 42.9% and 64.1%; The expression of both was correlated with histological classification and differentiation of carcinoma.Conclusion Detection of p21W AF1 gene and p53 protein expression may have significant value in the prognosis of tuberculosis with lung cancer