降纤酶与甘露醇联合治疗急性脑梗死的疗效观察

Therapeutic effect observation of combined defibrase with mannitol in treating acute cerebral infarction.

目的评价降纤酶与甘露醇联合治疗脑梗死的疗效。方法 64例急性脑梗死病例随机分为治疗组(34例)和对照组(30例),前者给予降纤酶10 U 每日1次静滴共14 d,20%甘露醇250 mL 每日2次静滴共14 d。对照组仅给予降纤酶静滴。治疗前后分别进行神经功能缺损评分(NDF)及日常生活能力评估(Barthel指数),观察疗效及不良反应。结果治疗后治疗组较对照组神经功能缺损及 Barthel 指数均明显改善,两组相比差异显著(P<0.01),治疗组总有效率明显高于对照组(P<0.05)。结论降纤酶与甘露醇联合冶疗急性脑梗死较单用降纤酶更加有效。

Objective To analyse the clinical efficacy of combined defibrase with mannitol in treating acute cerebral in- farction.Methods 64 cases with acute cerebral infarction were randomly divided into treated group (34 cases) and control group (30 cases),The patients in treated group were treated intravenously with defibrase 10 U per diem and 20% mannitol 250 mL twice a day,The 30 patients in control group treated with defibrase alone.The treatment course of both groups was 14 days,the nerve function deficit score was evaluated before and the 15th day,the routine life abili- ty (Barthel Index) was evaluated,Therapeutic efl'ects and adverse effects were observed.Results After treatment, The nerve function deficit score and The Barthel Index improved much more than those of the control group (P<0.01), The total effective rate in treated group was higher than that in control group (P<0.05).Conclusion Combined defi- brase with mannitol in treating acute cerebral infarction are more effective than that of single defibrase.