摘要
目的探讨乌司他丁(UTI)联合血必净对脓毒症患者肝、肾功能的保护作用。方法将64例脓毒症患者随机分为UTI联合血必净组和常规组。UTI联合血必净组加用UTI 30万单位,溶于0.9%生理盐水50mL,静脉滴注,每日2次;血必净50mL溶于0.9%生理盐水100mL,每日2次,共7d;常规组治疗两组相同。于治疗前和治疗后第8天测定血浆C反应蛋白(CRP)水平、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、IL-8水平及肝肾生化指标。结果 UTI联合血必净组、常规组治疗后CRP、TNF-α、IL-6、IL-8水平与治疗前比较,差异均有统计学意义(均P<0.05);两组血浆丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、肌酐(Cr)、尿素(BUN)、尿酸(UA)较治疗前明显降低(P<0.05)。以上指标治疗后UTI联合血必净组较常规组比较差异均有统计学意义(均P<0.05)。结论 UTI联合血必净可以显著降低脓毒症患者CRP、TNF-α、IL-6、IL-8水平,对肝肾生化指标有很大改善。UTI联合血必净对脓毒症患者的器官功能有较好的保护作用。
Objective To investigate the protective mechanism and efficacy of ulinastatin(UTI)combined with xuebijing on level of C-reactive protein(CRP)、interleukin-6(IL-6)、interleukin-8(IL-8)、tumor necrosis factor-α(TNF-α)and kidney liver organ function in patients with sepsis.Methods Sixty-foure patients with sepsis were randomly divided into UTI combined with xuebijing group and control group.The intravenous drip,two times a day each of the 30 0000 units UTI were given,accession to the 50 mL,0.9% physiological saline and xuebijing injection 50 mL,accession to the 100 mL,0.9% physiological saline for 7 days in UTI group.The routin treatment was given to two groups of the same.TNF-α,IL-6,IL-8,CRP indexes and other plasma biochemistrial indexes were determined before the treatment and 8 days after the treatment.Results After the treatment,the level of TNF-α,IL-6,IL-8,CRP significantly decreased in two groups(all P<0.05),and the decrease was more obvious in UTI and xuebijing group,compared with control group(all P<0.05).Plasma alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine(Cr),blood urea nitrogen(BUN),blood urea acid(UA)were significantly decreased in two groups after the treatment(P<0.05),and after the treatment the decreases of all these indexes were more marked in UTI and xuebijing group(P<0.05).Conclusion UTI combine with xuebijing has beneficial effects on the protection of organ function in patients with sepsis.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2014年第S1期113-116,共4页
Chinese Journal of Practical Internal Medicine
