瑞舒伐他汀与依折麦布联用对缺血性脑血管病患者血脂及颈动脉硬化斑块影响

Effects of combination of rosuvastatin with ezetimibe on blood lipids and carotid atherosclerosis plaques in the patients with ischemic cerebrovascular disease

目的探讨瑞舒伐他汀与依折麦布联用对缺血性脑血管病患者血脂及颈动脉硬化斑块的疗效。方法选择伴有血脂异常及颈动脉硬化的缺血性脑血管病患者100例为研究对象。采用随机数字表法将患者分为两组,常规组48例,给予常规药物及瑞舒伐他汀治疗;对照组52例,在对照组治疗基础上加用依折麦布治疗。两组均治疗6个月,比较两组治疗前后的血脂及颈动脉内-中膜厚度、颈动脉斑块数量的变化。结果治疗6个月后,两组患者血脂及颈动脉内-中膜厚度、颈动脉斑块数量均较治疗前明显改善,但对照组指标明显低于常规组(P<0.01)。结论瑞舒伐他汀联用依折麦布,可有效降低血脂水平及逆转颈动脉硬化斑块,值得临床推广。

Objective To investigate the effects of combination of rosuvastatin with ezetimibe on blood lipids and carotid atherosclerosis plaques in the patients with ischemic cerebrovascular disease(ICD). Methods One hundred of ICD patients with abnormal blood lipids and carotid atherosclerosis were randomly divided into two groups, the routine group(n=48) treated with conventional drugs and rosuvastatin and the control group(n=52) with ezetimibe treatment based on the routine group. The patients in the two groups were treated 6 months, and the changes of blood lipids, the thickness of carotid intima-media and the amount of carotid atherosclerosis plaque before and after treatment in the two groups were compared. Results Compared with before treatment, the blood lipids levels, the thickness of carotid intima-media and the amount of carotid atherosclerosis plaque after treatment in the two groups were significantly improved, but the control group better than the routine group(P<0.01). Conclusion The combination of rosuvastatin with ezetimibe may reduce the blood lipids levels and carotid atherosclerosis plaques in ICD patients effectively, which deserves to be spread.