血浆D-二聚体 总胆汁酸在不同Child-Pugh分级肝癌患者中的变化及临床意义

Changes and clinical significance of plasma D-dimer, total bile acid in different Child-Pugh grades of patients with hepatocellular carcinoma

目的探讨肝癌患者不同Child-Pugh分级中D-二聚体及总胆汁酸的变化及其临床意义。方法将肝癌患者按Child-Pugh分级分为A、B、C三组,分析各组之间D-二聚体及总胆汁酸的变化。结果血浆D-二聚体浓度在A、B、C三组呈逐渐上升趋势,各组间比较差异有统计学意义(P<0.05),总胆汁酸在A、B、C三组呈先上升再下降趋势,A组及C组明显小于B组,差异有统计学意义(P<0.05)。A组与C组之间差异无统计学意义(P>0.05)。结论D-二聚体可作为肝癌患者预后的相关指标。总胆汁酸可反映早期肝功能损害情况,但随着肝功能损害加重,其数值反而下降,不能反应后期肝功能的变化情况。

Objective To explore the changes and clinical significance of D-dimer, total bile acid (TBA) in patients with hepatocellular carcinoma. Methods All hepatocellular carcinoma patients were divided into three groups according to Child-Pugh grade(Group A/B/C),than the changes of D-dimer and TBA in each group were analyzed by SPSS software. Results The indexes of D-dimer in the childpugh A, B, C have an upward tendency and the diffence was of statistical sigificance(P<0.05). The indexes of TBA in the child-pugh B went up higher than child-pugh A, C and the diffence was of statistical sigificance(P<0.05). The indexes of TBA in the child-pugh A, C have no obvious difference.. Conclusion The indexes of D-dimer can provide prognosis of hepatocellular carcinoma, but the indexes of TBA can not.