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疑似肿瘤相关性血栓性微血管病死亡1例报道并文献复习

One death case of cancer-associated TMA and literature review
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摘要 肿瘤相关性血栓性微血管病(TMA)是一种肿瘤继发的癌栓性微血管病,在临床上主要表现为微血管病性溶血性贫血(MAHA),血小板减少,血栓形成及多器官功能损伤[1]。实验室检查往往发现Coombs试验(抗人球蛋白试验)阴性,外周血涂片中可见破碎红细胞[2]。此病于1962年由Brain首先报道[3],其起病隐匿,误诊、漏诊率高.
作者 侯婕 李碧娟 HOU Jie;LI Bi-juan(Department of Blood Transfusion,Xiangya Hospital of Central South University,Changsha 410008,China)
机构地区 中南大学湘雅医院输血科
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2018年第A02期73-75,共3页 Chinese Journal of Practical Internal Medicine
关键词 肿瘤相关性血栓性微血管病 微血管性溶血性贫血 血小板减少症 血浆置换 血栓性血小板减少性紫癜 cancer-associated thrombotic microangiopathy microvascular hemolytic anemia thrombocytopenia plasma exchange thrombotic thrombocytopenic purpura
分类号 R730.5 [医药卫生—肿瘤]
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  • 1Mayer SA,Aledort LM.Thrombotic microangiopathy:differential di-agnosis,pathophysiology and therapeutic strategies[J].Mt Sinai J Med,2005,72(3):166-175.
  • 2Smith KE,Wjlker PR,Reiter PL,et al.Antibiotic Treatment of Esch-erichia eoli 0157 Infection and the Risk of Hemolytic Uremic Syn-drome.Minnesota[J].Pediatr Infect Dis J,2011,31(1):37-41.
  • 3Safdar N,Said A,Gangnon RE,et al.Risk of hemolytic uremic syn-drome after antibiotic treatment of Eseheriehia coli 0157:H7 enteri-tis:a meta-analysis[J].Jama,2002,288(8):996-1001.
  • 4Ahn CK,Holt NJ,Tarr PI.Shiga.toxin producing Escherichia coli and the hemolytic uremic syndrome:what have we learned in the past 25years[J].Adv Exp Med Biol,2009,634:l-17.
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  • 7Andreas G,Sigrun F,Peter A,et al.Treatment of severe neurological deficits with IgG depletion throush immunoadsorption in patients with Escherichia coli 0104:H4-associated hacmolytie uraemic syndrome:a prospective trial[J].The Lancet,2011,[Epub ahead of print].
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中国实用内科杂志
2018年 第A02期

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