EB病毒引起慢性活动性肝炎的早期诊断和治疗

Early diagnosis and treatment of chronic active Epstein-Barr virus hepatitis

非嗜肝病毒如Epstein-Barr病毒(EBV)在人群中的感染率高,具有感染-潜伏-活化的生物学特性,可引起传染性单核细胞增多症(IM)、慢性活动性EBV感染(CAEBV)及EBV相关肿瘤等多种疾病。EBV相关疾病临床表现复杂、多样,无论是急性感染、慢性感染或是相关并发症均可导致不同程度的肝损伤。CAEBV可以诱发慢性活动性EBV肝炎(CAEBVH),甚至出现肝衰竭,患者预后差,病死率高。早期识别诊断及多学科协作治疗CAEBVH是改善患者预后的关键。文章将就CAEBVH的诊断、治疗进展进行综述,为临床医生早期诊断,规范治疗CAEBVH提供参考。

Non-hepatotropic viruses such as Epstein-Barr virus(EBV)has high infection rate in the population with biological characteristics of infective-latent-activation.EBV-related diseases including infectious mononucleosis(IM),chronic active EBV infection(CAEBV),EBV-related tumors and other diseases are complex and diverse,and all these can lead to varying degrees of liver damage.CAEBV can induce hepatitis(chronic active Epstein-Barr virus hepatitis,CAEBVH)or even liver failure.The prognosis of the disease is poor and the mortality rate is high.Early identification,diagnosis,and multidisciplinary collaborative treatment of CAEBVH are key to improving the prognosis of patients.This article will review the diagnosis and treatment progress of CAEBVH,and provide references for clinicians to diagnose and treat CAEBVH.