幽门螺杆菌的广泛根除是否会导致耐药性增加

Whether the eradication of Helicobacter pylori will result in antibiotic resistance

幽门螺杆菌(Helicobacter pylori,Hp)是一种持续性感染,全球人群感染率超过60%。其与许多胃肠道疾病有关,并且可导致恶性肿瘤的发生。幽门螺杆菌感染已成为广泛根除的指征,根除幽门螺杆菌也可有效预防相关胃肠道疾病的发生。由于抗生素的广泛使用和不良反应出现的增多,根除率呈现降低的趋势。近年来,旨在降低幽门螺杆菌耐药的新治疗方法是研究的焦点。文章将对幽门螺杆菌耐药及广泛根除的现状进行阐述,探讨广泛根除和耐药的关系。

Helicobacter pylori(Hp)is a persistent infection that affects more than 60%of the global population.It is associated with many gastrointestinal diseases and even can lead to cancer.H.pylori-infected individuals should be offered eradication therapy,which can also prevent the morbidity of gastrointestinal diseases effectively.Due to the extensive use of antibiotics and the increase of adverse reactions,the eradication rate shows a downward tendency.In recent years,researches have been done focusing on the treatments which can reduce the antibiotic resistance of Helicobacter pylori.This article aims to elaborate the current situation of antibiotic resistance and the eradication of Helicobacter pylori,and discuss the relationship between them.