尿synaptopodin在糖尿病肾病诊断中价值研究(附75例分析)

Study on clinical value of urinary synaptopodin in diabetic nephropathy

目的探讨糖尿病肾病患者尿synaptopodin水平及其与临床病理的关系,以期为糖尿病肾病诊断提供新的生物标志物。方法选取2016年9月至2017年12月在郑州大学第一附属医院和兰州大学第二医院75例经肾穿刺活检确诊的糖尿病肾病患者为研究对象,收集患者的临床和病理资料,检测患者尿synaptopodin水平,分析尿synaptopodin与患者临床、病理的关系。结果结节性糖尿病肾病患者和弥漫硬化性糖尿病肾病患者尿synaptopodin/β-Actin水平显著高于早期糖尿病肾病组(P<0.05),相关性分析提示尿synaptopodin/β-Actin与患者24 h尿蛋白量(r=0.408,P=0.014)、尿点式白蛋白(r=0.0.341,P=0.043)、血清肌酐(r=0.386,P=0.021)具有正相关关系。结论糖尿病肾病患者尿synaptopodin水平显著升高,且与患者临床和病理相关,可成为糖尿病肾病潜在的新型生物标志物。

Objective To investigate the relationship between urinary synaptopodin levels and clinical pathology in patients with diabetic nephropathy,in order to provide new biomarkers for diabetic nephropathy.Methods Seventy-five patients with diabetic nephropathy confirmed by renal biopsy were enrolled in this study.Those patientsin was in the First Affiliated Hospital of Zhengzhou University and the Second Hospital of Lanzhou University from September 2016 to December 2017.The level of urinary synaptopodin was measured and the relationship between urinary synaptopodin and clinical and pathological changes was analyzed.Results The levels of urinary synaptopodin/β-Actin in patients with nodular diabetic nephropathy and diffuse sclerosing diabetic nephropathy were significantly higher than those in the early diabetic nephropathy group(P<0.05).Correlation analysis indicated urinary synaptopodin/β-Actin had a positive correlation with 24-hour urine protein(r=0.408,P=0.014),urinary albumin(r=0.0.341,P=0.043)and serum creatinine(r=0.386,P=0.021)Conclusion The level of urinary synaptopodin in patients with diabetic nephropathy is significantly increased and is associated with clinical and pathological conditions,which may become a potential new biomarker for diabetic nephropathy.