重组人干扰素α2b治疗重型早期手足口病疗效观察

Effects of recombinant human interferon α-2b on severe hand-foot-and-mouth disease

目的探讨重组人干扰素α2b治疗小儿手足口病的临床疗效及其对不同手足口病病毒学亚型的疗效。方法选取蚌埠医学院第一附属医院儿科2016年4—11月150例重症手足口病早期患儿随机分为对照组(75例)和观察组(75例),对照组患儿给予常规抗病毒、加强口腔及皮肤护理等治疗,治疗组患儿在此基础上联合使用重组人干扰素α2b稀释液外用及涂口治疗,比较2组患儿的临床疗效。结果治疗组患儿临床有效率明显高于对照组,差异有统计学意义(P<0.05);治疗组患儿发热消退时间、皮疹消退时间、口腔疱疹消退时间及住院时间均比对照组缩短,差异有统计学意义(P<0.05),治疗后2组患儿WBC、CRP、AST、ALT及CK-MB水平均较治疗前有所降低,且治疗组患儿上述指标的下降较对照组患儿更明显,差异有统计学意义(P<0.05);重组干扰素α2b对EV71型和CA16型手足口病患儿的疗效优于其他肠道病毒(P<0.05)。结论重组人干扰素α2b稀释外用及涂口治疗手足口病疗效显著,能有效缓解手足口病患儿特别是EV71型和CA16型患儿的临床症状、缩短住院时间,同时能有效改善患儿的肝功能、减轻心肌损害,抗炎作用显著,疗效确切,未见不良反应。

Objective To investigate the clinical effects of recombinant human interferon α-2 b on hand-foot-and-mouth disease( HFMD) in children,and outcome assessment of the diseases caused by different viral infection. Methods A total of 150 children with severe HFMD were enrolled and randomly divided into control group and observation group with75 cases in each group. The children in the control group received the routine antiviral therapy with intensive oral and skin care,while the children in the observation group received the routine therapy as well as recombinant human interferon α-2 b dilution for topical external treatment. The clinical efficacy was compared between the two groups. Results The clinical efficiency of the observation group was superior to the control group,the difference was significant( P < 0. 05). The fever duration,deflorescence and oral herpes fading,and the length of stay were obviously shorter as compared with the control group( P < 0. 05); After the treatment,the levels of WBC,CRP,AST,ALT and CK-MB were all decreased,especially in the observation group,the difference was statistically significant( P < 0. 05); EV71 and CA16 were more sensitive to recombinant human interferon alfa-2 b than other virus in patients with HFMD( P < 0. 05). Conclusion The curative effect of recombinant human interferon α-2 b dilution( topical external treatment or oral application) on HFMD patients is obviously. It can relieve the clinical symptoms,shorten the duration of hospital stays,improve the liver function and alleviate myocardial damage,especially in the children caused by EV71 and CA16. The anti-inflammatory effect of recombinant human interferon α-2 b is dramatically,and no adverse reactions have been found.