盐酸多奈哌齐片联合神经酸治疗脑白质疏松症伴认知障碍的临床疗效

Clinical Effects of Donepezil Hydrochloride Tablet Combined with Nervonic Acid in the Treatment of Leukoaraiosis and Cognition Disorders

目的探讨盐酸多奈哌齐片联合神经酸治疗脑白质疏松症(LA)伴认知障碍的临床疗效。方法选取2016年6月—2016年10月南京大学医学院附属鼓楼医院老年科收治的LA伴认知障碍患者60例,采用随机数字表法分为观察组与对照组,各30例。对照组患者予以盐酸多奈哌齐片治疗,观察组患者予以盐酸多奈哌齐片联合神经酸治疗;两组患者均连续治疗6周。比较两组患者治疗前后简易智力检查状态检查量表(MMSE)评分和神经元特异性烯醇化酶(NSE)水平。结果治疗前两组患者MMSE评分比较,差异无统计学意义(P>0.05);治疗后观察组患者MMSE评分高于对照组(P<0.05)。治疗前两组患者NSE水平比较,差异无统计学意义(P>0.05);治疗后观察组患者NSE水平低于对照组(P<0.05)。结论盐酸多奈哌齐片联合神经酸治疗LA伴认知障碍的临床疗效确切,可改善患者的认知功能和神经功能。

Objective To study the clinical effects of donepezil hydrochloride tablet combined with nervonic acid in the treatment of leukoaraiosis and cognition disorders. Methods A total of 60 patients with leukoaraiosis and cognition disorders in the Affiliated Drum Tower Hospital of Nanjing University Medical School form June 2016 to October 2016,they were dividren into control group and observation group,each of 30 cases. Control group were given donepezil hydrochloride tablet treatment,observation group were given donepezil hydrochloride tablet combined with nervonic acid treatment; both grups comtionuously treated for 6 weeks. The simple intelligent status scale( MMSE) scores and NSE level before and after treatment were compared between the two groups. Results Before treatment,MMSE scores showed no significant differences between the two groups( P> 0. 05),after treatment,MMSE scores of the observation group was higher than taht of the control group( P < 0. 05). Before treatment,NSE level showed no significant differences between the two groups( P > 0. 05),after treatment,NSE level of the observation group was lower than taht of the control group( P < 0. 05). Conclusion Donepezil hydrochloride tablet combined with nervonic acid has certain clinical effect in traeting leukoaraiosis and cognition disorders,can improve cognitive function and nerve function.