不同剂量尼可刹米注射液治疗慢性阻塞性肺疾病急性加重期患者的临床疗效

Clinical Effects of Different Doses of Nikethamide Injection in Treatmenting Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨不同剂量尼可刹米注射液治疗慢性阻塞性肺疾病急性加重期患者的临床疗效。方法选取2014年10月—2016年10月核工业四一七医院收治的慢性阻塞性肺疾病急性加重期患者72例,采用随机数字表法分为观察组与对照组,每组36例。在双水平无创正压通气治疗基础上,对照组患者予以小剂量尼可刹米注射液治疗,观察组患者予以大剂量尼可刹米注射液治疗;两组患者均连续治疗4d。比较两组患者治疗前后血气分析指标[pH值,动脉血氧分压(PaO_2),动脉血二氧化碳分压(PaCO_2)]。结果治疗前两组患者pH值、PaO_2、PaCO_2比较,差异无统计学意义(P>0.05);治疗后观察组患者pH值、PaO_2高于对照组,PaCO_2低于对照组(P<0.05)。结论大剂量尼可刹米注射液治疗慢性阻塞性肺疾病急性加重期患者的临床疗效好于小剂量尼可刹米注射液,可有效改善患者缺氧症状。

Objective To study the clinical effects of different doses of nikethamide injection in treatmenting acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 72 patients with acute exacerbation of chronic obstructive pulmonary disease,they were dividren into control group and observation group,each of 36 cases. Based on double the level of noninvasive positive pressure ventilation therapy,control group were given low dose nikethamide injection treatment,observation group were given high dose nikethamide injection treatment; both grups comtionuously treated for four days. Blood gas analysis index were comparde between the two groups before and after treatment. Results Before treatment, pH, PaO_2,PaCO_2 showed no significant differences between the two groups( P > 0. 05),after treatment,pH,PaO_2 of treatment froups were higher than those of control group, PaCO_2 of treatment froups was lower than those of control group( P < 0. 05).Conclusion High dose nikethamide injection treatment of chronic obstructive pulmonary disease in patients with acute aggravating period of clinical curative effect is better than that of low dose of nikethamide injection,can effectively improve the symptoms of patients with hypoxia.