依达拉奉在急性期脑梗死患者中的有效性及安全性分析

Analysis of Effectiveness and Safety of Edaravone in Patients with Acute Cerebral Infarction

目的分析研讨依达拉奉治疗急性期脑梗死疾病的有效性和安全性。方法 2015年9月—2017年2月期间四川省眉山市彭山区人民医院收治的80例急性期脑梗死患者,采用1∶1随机数字法分2组,各40例。对照组接受神经节苷脂治疗,研究组接受神经节苷脂+依达拉奉治疗,观察两组治疗状况,如神经功能缺损程度(NIHSS评分)、改良巴氏指数(BI)、疗效等并比较。结果研究组治疗总疗效92.50%高于对照组77.50%(P<0.05)。两组患者NIHSS、BI评分治疗前比较,差异无统计学意义(P>0.05);治疗后,研究组NIHSS评分低于对照组,BI评分高于对照组(P<0.05)。两组患者炎性因子(CRP、IL-6、TNF-α)状况治疗前比较,差异无统计学意义(P>0.05),治疗后研究均低于对照组(P<0.05)。结论建议临床治疗急性期脑梗死疾病可在神经节苷脂药物治疗基础上,再给予依达拉奉药物,其疗效突出,对神经恢复有促进作用,患者炎症因子得到降低,值得持续推广。

Objective To analyze and discuss effectiveness and safety of edaravone in patients with acute cerebral infarction.Methods 80 cases of acute cerebral infarction treated in People’s Hospital of Pengshan District from September 2015 to February 2017 were divided into two groups by 1∶1 random number method,with 40 cases in each group.The control group were treated with ganglioside,while the study group were treated with ganglioside combined with edaravone.The treatment conditions of two groups were observed,such as the degree of nerve function defect(NIHSS score),the improved pasteurized index(BI),and the clinical effect,and so on.Results The total treatment effect in the study group was 92.50%,which was higher than 77.50%in the control group(P<0.05).The NIHSS and BI scores of two groups before treatment had no significant difference(P>0.05).After treatment,the NIHSS score in the study group was lower than that in the control group,and the BI score was higher than that in the control group(P<0.05).The status of inflammatory factors(CRP,IL-6,TNF-α)of two groups before treatment had no significant difference(P>0.05).After treatment,items of the study group was lower than that in the control group(P<0.05).Conclusion It is suggested that treating acute cerebral infarction by ganglioside drugs on the basis of treatment is useful,which promote the treatment of edaravone,its clinical effect are prominent,and it has promoting effect on nerve recovery,and the patient’s inflammatory factors are reduced,thus it is worth continuing to promote.