静脉氨溴索与吸入布地奈德混悬液联合应用于新生儿肺炎治疗的临床效果分析

The Clinical Effect of Combination of Intravenous Ambroxol and Inhaled Budesonide Solution in the Treatment of Neonatal Pneumonia

目的研究临床氨溴索静脉用药联合吸入布地奈德混悬液治疗新生儿肺炎的效果。方法选择江苏省连云港市市立东方医院2017年4月—2018年4月中的60例肺炎新生儿进行研究,按照新生儿接受治疗的不同分为观察组和对照组,各30例。对照组接受布地奈德混悬液雾化吸入治疗,观察组联合应用氨溴索静脉滴注、布地奈德混悬液雾化吸入治疗,比较两组效果。结果观察组治疗后总有效率为93.33%,明显高于对照组治疗总有效率70.00%(P<0.05);观察组治疗后炎症因子指标IL-10、IL-6、IL-2为(10.48±1.54)ng/ml、(180.54±20.33)ng/ml、(30.08±4.57)pg/ml,均明显优于对照组(16.33±1.29)ng/ml、(267.55±25.44)ng/ml、(24.63±4.21)pg/ml(P<0.05)。结论氨溴索静脉滴注、布地奈德混悬液雾化吸入治疗新生儿肺炎能够使新生儿临床症状得到更迅速缓解,能够更明显改善新生儿炎症因子水平,值得临床推广。

Objective To study the effect of clinical ambroxol intravenous drug combined with inhaled budesonide solution in the treatment of neonatal pneumonia.Methods From April 2017 to April 2018 60 cases of neonatal pneumonia were divided into the observation group and the control group according to different ways of newborns,30 cases in each group.Control group accepted cloth to endure dehua solution atomization inhalation therapy,observation group received combined use of ammonia bromine somalia’s intravenous drip,cloth to nai dehua solution atomization inhalation therapy,results of two groups were compared.Results After treatment,the total effective rate was 93.33%in the observation group,which was significantly higher than 70.00%in the control group(P<0.05).After treatment,the inflammatory cytokines of the observation group were il-10,il-6,and il-2(10.48±1.54)ng/ml,(180.54±20.33)ng/ml,(30.08±4.57)pg/ml,both significantly superior to the control group(16.33±1.29)ng/ml,(267.55±25.44)ng/ml,(24.63±4.21)pg/ml,P<0.05.Conclusion Ambroxol intravenous infusion and budesonide solution atomization inhalation in the treatment of neonatal pneumonia can rapidly relieve the clinical symptoms of neonates and significantly improve the levels of inflammatory factors in neonates,which is worthy of clinical promotion.