氯吡格雷联合阿托伐他汀钙片治疗冠心病的临床疗效及其对分泌型卷曲相关蛋白5、γ-干扰素水平的影响

Clinical Effect of Clopidogrel Combined with Atorvastatin Calcium Tablets on Coronary Heart Disease and Its Impact on SFRP5 and IFN-γ

目的分析氯吡格雷联合阿托伐他汀钙治疗冠心病的临床疗效及其对分泌型卷曲相关蛋白5(SFRP5)、γ-干扰素(IFN-γ)水平的影响。方法选取2017年1月—2018年1月绵阳市第三人民医院收治的冠心病患者94例,采用随机数字表法分为对照组和研究组,每组47例。在常规对症治疗基础上,对照组患者给予氯吡格雷治疗,研究组患者在对照组基础上给予阿托伐他汀钙片治疗;两组患者均连续治疗4周。比较两组患者临床疗效,治疗前后SFRP5、INF-γ水平及血脂指标〔包括总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)〕,并观察两组患者治疗期间不良反应发生情况。结果研究组患者总有效率为97.9%,高于对照组的76.6%(P<0.05)。治疗前两组患者SFRP5、INF-γ水平比较,差异无统计学意义(P>0.05);治疗后研究组患者SFRP5水平高于对照组,INF-γ水平低于对照组(P<0.05)。治疗前两组患者TG、TC、HDL-C、LDL-C比较,差异无统计学意义(P>0.05);治疗后研究组患者TG、TC、LDL-C低于对照组,HDL-C高于对照组(P<0.05)。研究组患者治疗期间不良反应发生率低于对照组(P<0.05)。结论氯吡格雷联合阿托伐他汀钙片治疗冠心病的临床疗效确切且安全性较高,可有效降低SFRP5水平,升高IFN-γ水平,改善血脂代谢。

Objective To analyze the clinical effect of clopidogrel combined with atorvastatin calcium tablets on coronary heart disease and its impact on SFRP5 and IFN-γ.Methods A total of 94 patients with coronary heart disease were selected in the Third People’s Hospital of Mianyang from January 2017 to January 2018,and they were divided into control group and study group according to random number table method,with 47 cases in each group.Based on conventional symptomatic treatment,patients in control group received clopidogrel,while patients in study group received atorvastatin calcium tablets based on that of control group;both groups continuously treated for 4 weeks.Clinical effect,SFRP5,IFN-γand blood lipid parameters(including TC,TG,HDL-C and LDL-C)before and after treatment were compared between the two groups,and incidence of adverse reactions was observed during treatment.Results Total effective rate in study group was 97.9%,which was statistically significantly higher than that in control group of 76.6%(P<0.05).No statistically significant difference of SFRP5 or INF-γwas found between the two groups before treatment(P>0.05);after treatment,SFRP5 in study group was statistically significantly higher than that in control group,while INF-γin study group was statistically significantly lower than that in control group(P<0.05).No statistically significant difference of TG,TC,HDL-C or LDL-C was found between the two groups before treatment(P>0.05);after treatment,TG,TC and LDL-C in study group were statistically significantly lower than those in control group,while HDL-C in study group was statistically significantly higher than that in control group(P<0.05).Incidence of adverse reactions in study group was statistically significantly lower than that in control group during treatment(P<0.05).Conclusion Clopidogrel combined with atorvastatin calcium tablets has certain clinical effect and relatively high safety in treating coronary heart disease,can effectively reduce the SFRP5 level,improve the IFN-γlevel,adjust the blood lipid metabolism.