摘要
目的考察唾液酸(sialic acid,SA)修饰盐酸多柔比星(doxorubicin hydrochloride,DOX)脂质体的肿瘤治疗效果。方法分别制备普通DOX脂质体、聚乙二醇化的DOX脂质体和SA修饰DOX脂质体,并以质量分数5%葡萄糖注射液和DOX溶液为对照,考察了3种脂质体对S180荷瘤小鼠的肿瘤治疗作用。结果 SA修饰DOX脂质体的肿瘤抑制率最高,为97.77%,与其他制剂比较具有极显著差异(P<0.01)。结论 SA修饰脂质体能够使DOX更大程度地发挥抗肿瘤作用,具有较好的临床应用前景。
Objective To evaluate the anti-tumor activity of sialic acid(SA)-modified doxorubicin(DOX)liposomes.Methods DOX solution(DOX-S),conventional DOX liposomes(DOX-CL),PEGylated DOX liposomes(DOX-PL)and SA-modified DOX liposomes(DOX-SAL)was prepared,respectively.The anti-tumor efficacies of above-mentioned formulations were investigated by S180 tumor-bearing mice.Results DOX-SAL exhibited the highest tumor inhibition rate of 97.77%,and significantly enhanced the survival time and quality of life of the mice.Conclusion DOX-SAL can improve the anti-tumor efficacy of DOX,and it may be a good candidate for clinical tumor therapy.
作者
李瑭
宋艳志
刘铭琦
熊雁
邓意辉
LI Tang;SONG Yanzhi;LIU Mingqi;XIONG Yan;DENG Yihui(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2019年第9期755-759,共5页
Journal of Shenyang Pharmaceutical University
基金
国家自然科学基金资助项目(81703456)
辽宁省科技厅基金资助项目(201601140)
关键词
脂质体
盐酸多柔比星
唾液酸
主动靶向
抗肿瘤
liposome
doxorubicin hydrochloride
sialic acid
active target
anti-tumor
