尿系列蛋白检测在无症状高尿酸血症肾损害早期诊断中的价值

Significance of the Urine Protein Detecting in the Initial Diagnosis of Asymptomatic Hyperuricemia Injury of Kidney Patients

目的:探讨尿中微量白蛋白(MA)、α1-微球蛋白(A1M)、免疫球蛋白(IGU)和转铁蛋白(TRU)对无症状性高尿酸血症引起肾损害早期诊断的价值。方法:利用速率散射免疫比浊法测定了85例高尿酸血症患者和53例健康人的晨尿中四种尿微量蛋白的含量。结果:无症状高尿酸血症患者四种微量蛋白的水平显著高于正常对照者水平(P<0.01),无症状高尿酸血症尿MA、A1M、IgU、TRU的异常率分别为32.9%、36.5%、10.5%、44.7%;且与患者年龄、血尿酸水平密切相关。结论:MA、A1M、IgU、TRU是诊断无症状高尿酸血症早期肾损害的敏感指标,其中以TRU最敏感,联合测定尿MA、A1M、IgU、TRU有助于无症状高尿酸血症早期肾损害的诊断。

Objective To investigate the significance of microprotein(MA),α-microprotein(A1M) immunoglobulin(IgU) andtransferrin(TRU) in diagnosing the initial renal injury in asymptomatic hyperuricemia patients.Methods MA,A1M,IGU and TRU from 85 hyperuricemia patients and 53 healthy comparisons were measured by rate nephelometry.Results MA,A1M,IGU and TRU in asymptomatic hyperuricemia patients were significantly higher than that in 50 healthy comparisons(P<0.01).The abnormity rate of MA,A1M,IGU and TRU in asymptomatic hyperuricemia are separately 32.9%,36.5%,10.5%,44.7%;it is related to the patient age and the level of the blood uric acid closely.Conclusion MA,A1M,IgU and TRU are sensitive indexes in diagnosing the initial renal injury in asymptomatic hyperuricemia,and the most sensitive is TRU,MA,A1M,IGU and TRF can help to diagnose the initial renal injury in asymptomatic hyperuricemia patients.