胃癌与红细胞Lewis表型的相关性研究

Study on Correlation Between Gastric Cancer and Erythrocyte Lewis Phenotypes

目的:探讨人类红细胞Lewis表型的不同是否与胃癌的发生有关。方法:应用微柱凝胶技术对63例胃癌患者及120名健康供血者的血液标本进行Lewis表型检测,比较分析两组人群红细胞Lewis表型的表达频率。结果:胃癌患者红细胞kwis(a-b+)表型频率明显高于健康对照组(79.4%VS 61.7%,P<0.05)。而其Lewis(a+b-)表型频率明显低于健康对照组(9.5%VS 22.5%,P<0.05)。结论:Lewis(a-b+)表型可能是胃癌易发的一个危险因素。

Objective To investigate whether humans erythrocyte Lewis phenotypes correlated with the risk of gastric canc- ers.Methods Erythrocyte Lewis phenotypes of 63 gastric cancer patients and 120 blood donors were checked by microcolumn gel technique,analyzing and comparing the frequencies of erythroeyte Lewis phenotypes in the two groups.Results These gas- tric cancer patients had a significantly higher rate of Lewis(a-b+) phenotype and a significantly lower rate of Lewis(a+b -) phenotype than the blood donors(79.4% VS 61.7%;9.5% VS 22.5%,P<0.05).Conclusion Lewis (a-b+) phe- notype could be a risk factor for gastric cancer.